Planta Medica, Table of Contents Planta Med 1999; 65(8): 740-743DOI: 10.1055/s-1999-14054 Original Paper Georg Thieme Verlag Stuttgart · New YorkNew Triterpenoids with Antibacterial Activity from Zizyphus joazeiro Wolfgang Schühly1 , Jörg Heilmann1 , Ihsan Çalis2 , Otto Sticher1 1 Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, Zürich, Switzerland 2 Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract The stem bark of the Brazilian medicinal plant Zizyphus joazeiro C. Mart. was phytochemically investigated. Three known compounds (betulinic, ursolic and alphitolic acid) and three new derivatives of betulinic acid, 7β-(4-hydroxybenzoyloxy)-betulinic acid, 7β-(4-hydroxy-3′-methoxybenzoyloxy)-betulinic acid and 27-(4-hydroxy-3′-methoxybenzoyloxy)-betulinic acid which showed a considerable activity against Gram-positive bacteria were isolated from the dichloromethane extract. The structures were established on the basis of NMR spectroscopy and mass spectrometry. Key words Zizyphus joazeiro - Rhamnaceae - antibacterial activity - betulinic acid - 7β-(4-hydroxybenzoyloxy)-betulinic acid - 7β-(4-hydroxy-3′-methoxybenzoyloxy)-betulinic acid - 27-(4-hydroxy-3′-methoxybenzoyloxy)-betulinic acid PDF (189 kb)
