Synthesis 1999; 1999(2): 254-257
DOI: 10.1055/s-1999-3395
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Trimolecular Condensation of Substituted Indoles with Paraformaldehyde and Meldrum's Acid. Convective Heating versus Microwave Irradiation. A Comparative Study

Csaba Nemes* , Jean-Yves Laronze
  • *UPRES A CNRS 6013, Faculté de Pharmacie, Université de Reims-Champagne-Ardenne, 51, rue Cognacq-Jay, 51096 Reims Cédex, France; Fax +33(3 26)89 80 29; E-mail: [email protected]
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Publikationsdatum:
31. Dezember 1999 (online)

Results obtained in a comparative study on the trimolecular condensation of substituted indoles 1 with paraformaldehyde and Meldrum's acid using convective heating vs. microwave irradiation are described. Both methods afforded adducts 2 together with their hydroxymethylated derivatives 3 in good yields. Although in both cases the yields are about the same, the microwave irradiation was found to be more advantageous, as this procedure makes possible to considerably reduce the reaction times and to obtain cleaner reaction mixtures.