Purpose: The study aimed at MRI evaluation of aseptic osteonecrosis (AON) in children over
the course of hyperbaric oxygen (HBO) therapy. Material and Methods: Retrospective analysis of 72 MRI studies in 20 children presenting with AON during
chemotherapy. Two groups were differentiated: Gr. I (n = 8) was treated exclusively
with relief of weightbearing structures, Gr. II (n = 12) was additionally treated
with HBO therapy. The MRI examinations were evaluated by a point-score system (1 -
6 points) by two radiologists. Results: Gr. II initially showed more severe findings (average score: 3.4) in comparison to
Gr. I (average score: 2.65). During the follow-up time period the average scores rose
to 3.2 score-points in Gr. I and 4.1 points in Gr. II. No statistically significant
difference was evident between the two groups in the course of AON. Conclusion: The majority of chemotherapy associated AON which initially present with advanced
findings show a progression in MRI over their further course. HBO therapy in addition
to the relief of affected weightbearing structures statistically shows no significant
improvement in MRI morphology during the course of the treatment.
Key words:
MRI - Hyperbaric Oxygenation - Chemotherapy - Osteonecrosis
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Axel Scherer, MD
Institute of Diagnostic Radiology Heinrich-Heine University
Moorenstr. 5
40225 Düsseldorf
Phone: + 49- 211- 8 117 752
Fax: + 49- 211- 8 116 299
Email: scherera@uni-duesseldorf.de
