VARIATIONS IN NEUTROPHIL COUNT IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME WHO SUBSEQUENTLY DEVELOPED CHRONIC LUNG DISEASE

David Kohelet; Eliana Arbel; Ami Ballin; Michael Goldberg

doi:10.1055/s-2000-9279

American Journal of Perinatology, Table of Contents

Am J Perinatol 2000; Volume 17(Number 03): 159-162
DOI: 10.1055/s-2000-9279

VARIATIONS IN NEUTROPHIL COUNT IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME WHO SUBSEQUENTLY DEVELOPED CHRONIC LUNG DISEASE

David Kohelet^1,4 , Eliana Arbel^1,4 , Ami Ballin⁴ , Michael Goldberg^3,4

¹Department of Neonatology, Edith Wolfson Medical Center, Holon
²Department of Pediatric Hematology, Edith Wolfson Medical Center, Holon
³Department of Neonatology, Assaf Harofeh Medical Center, Zerifin
⁴Sackler School of Medicine, Tel Aviv University, Israel

Abstract

ABSTRACT

Neutrophil counts were studied in 62 preterm infants receiving mechanical ventilation for neonatal respiratory distress syndrome (NRDS). Exploratory analysis indicated that the severity of NRDS, as demonstrated by fractional inspired oxygen (FiO₂), mean airway pressure (MAP), arterial-alveolar PO₂ ratio (a/APO₂) and oxygenation index (OI), was correlated with percentage change of neutrophil counts during the first 5 days of life. Further analysis demonstrated that infants with NRDS who subsequently developed chronic lung disease (CLD) (n = 21) had statistically significant differences in variation of neutrophil counts when compared with the remainder (n = 41) without CLD (-35.0% ± 4.3 vs. -16.9% ± 5.8, p < 0.02). It is concluded that significant variations in neutrophil counts during the first 5 days of life may be found in infants with NRDS who subsequently develop CLD and that these changes may have predictive value regarding the development of CLD.

KEYWORD

CLD - neutrophil counts - preterm infant - RDS

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References

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