Zusammenfassung
Der apoptotische Zelltod ist im letzten Jahrzehnt zunehmend ins Interesse bei verschiedenen
neurobiologischen und neuroimmunologischen Fragestellungen gerückt. Obwohl Apoptose
einen primär morphologisch definierten Begriff darstellt, ist er mit einer Reihe molekular-definierter
Vorgänge verbunden und hat vielfältige funktionelle Bedeutung. Wir besprechen im Folgenden
die verfügbaren Nachweismethoden für Apoptose, das Auftreten von T-Zellapoptose bei
neuroimmunologischen Erkrankungen sowie den apoptotischen neuronalen Zelltod in Neurodegeneration
und Ischämie. Die therapeutische Nutzung durch Induktion von Apoptose bei entzündlichen
Erkrankungen bzw. deren Verhinderung bei degenerativen Prozessen wird zukünftig nur
in enger Kooperation verschiedener Forschungsrichtungen gelingen.
Apoptotic Cell Death in Neuroinflammatory and Neurodegenerative Diseases
Apoptotic cell death has gained increased importance in neurobiology and neuroimmunology.
Although apoptosis is per se defined by morphology, it is intimately linked to a series of molecular events and
has a wide array of functional implications. Here, we summarise the available detection
assays for apoptosis and the current state of research concerning T cell apoptosis
in neuroimmunology and apoptotic neuronal cell death in neurodegeneration and ischemia.
There is a clear therapeutic potential by induction of apoptosis in inflammatory diseases.
Furthermore, protection from apoptotic cell death may be a promising tool in neurodegenerative
and ischemic processes. In the future, this will necessitate a close cooperation between
different fields of biology research.
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Priv.-Doz. Dr. Ralf Gold
Neurologische Universitätsklinik
Josef-Schneider-Straße 11
97080 Würzburg
Email: r.gold@mail.uni-wuerzburg.de
