In an attempt to elucidate the effect of vanadium compounds on the gene expression
of neuropeptide Y (NPY), vanadyl sulfate (VOSO4) was orally administrated at the dose of 1 mg/kg body weight into streptozotocin-induced
diabetic rats (STZ-diabetic rats) three times daily for 1 week. We found a marked
lowering of plasma glucose with a significant decrease of food and water intake in
these STZ-diabetic rats treated with VOSO4, although the weight gain was unaffected. The increase of hypothalamic NPY, both
the mRNA level and peptide concentration, in STZ-diabetic rats was also reduced by
this oral treatment of VOSO4. However, similar treatment of VOSO4 in normal rats failed to modify the feeding behavior and hypothalamic NPY gene expression.
These data suggest that decrease of hypothalamic NPY gene expression by VOSO4 is related to the recovery of hyperphagia in diabetic rats lacking insulin.
Key words:
Vanadyl Sulfate - Neuropeptide Y Gene Expression - Diabetic Rat
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E30-E35
Prof. J. T. Cheng
Department of Pharmacology,
College of Medicine, National Cheng Kung University
Tainan City, Taiwan
70101, R.O.C.
Phone: Phone:+ 886 (6) 237-2706
Fax: Fax:+ 886 (6) 238-6548
Email: E-mail:jtcheng@mail.ncku.edu.tw
