Zusammenfassung
Als Ursache klinisch unterschiedlicher Manifestationsformen einer Vasculitis allergica
konnte bei zwei Patienten eine chronische Hepatitis-C-Infektion mit assoziierter Kryoglobulinämie
Typ II nachgewiesen werden. Bei beiden Patientinnen bestand eine jahrelange Anamnese
der Vasculitis allergica. Unter kurzfristiger Therapie mit Glukokortikoiden und langfristiger
Behandlung mit alpha-Interferon bzw. alpha-Interferon und Ribavirin konnte in beiden
Fällen eine vollständige Rückbildung der Vasculitis allergica erreicht werden.
Hepatitis C Induced Cryoglobulinemia with Associated Allergic Vasculitis
In two patients presenting with clinically different types of allergic vasculitis
a chronic hepatitis C infection with associated cryoglubulinemia type II was documented.
Both female patients had a history of allergic vasculitis for several years. A complete
remission was achieved by short-term application of corticosteroids followed by long-term
treatment with interferon-alpha and interferon-alpha combined with ribavirin, respectively.
Literatur
- 01
Agnello V, Chung R T, Kaplan L M.
A role for hepatitis C virus infection in type II cryoglobulinemia.
N Engl J Med.
1992;
327
1490-1495
- 02
Alter M J, Margolis H S, Krawczynski H.
The natural history of community-acquired hepatitis C in the United States.
N Engl J Med.
1992;
327
1899-1905
- 03
Baker A L, Kaplan M M, Benz W C, Sidel J S, Wolfe H J.
Polyarteritis associated with Australia antigen-positive hepatitis.
Gastroenterology.
1972;
62
105-110
- 04
Brouet J-C, Clauvel J-P, Danon F, Klein M, Seligman M.
Biologic and clinical significance of cryoglobulins: A report of 86 cases.
Am J Med.
1974;
57
775-778
- 05
Cacoub P, Renou C, Rosenthal E.
Extrahepatic manifestations associated with hepatitis C virus infection.
Medicine.
2000;
79
47-56
- 06
Chouela E, Abeldano A, Panetta J.
Hepatitis C virus (anti-HCV): prevalence in psoriasis.
Int J Dermatol.
1996;
35
797-799
- 07
Di Bisceglie A M, Goodman Z D, Ishak K G, Hoofnagle J H, Melpolder J J, Alter H J.
Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis.
Hepatology.
1991;
14
969-974
- 08
Erhardt A, Petry W, Ebel M, Jablonowski H, Heintges T, Häussinger D.
Antivirale Therapie der Hepatitis C.
Z Gastroenterol.
2000;
38
259-269
- 09
Heckmann J G, Kayser C, Heuss D, Manger B, Blum H E, Neundorfer B.
Neurological manifestation of chronic hepatitis C.
J Neurol.
1999;
246
486-491
- 10
Hess G.
Virushepatitiden vom Typ C, D und E: virologische Diagnostik, Epidemiologie und klinischer
Verlauf.
Internist.
1991;
32
244-248
- 11 Imhof M, Ochsendorf F, Zeuzem S, Schöfer H.
Hepatitis-C-Virus-assoziierte Dermatosen. In: Plettenberg A, Meigel WN, Moll I (Hrsg) Dermatologie an der Schwelle zum neuen
Jahrtausend. Berlin, Heidelberg; Springer 2000
- 12
Johnson R J, Gretch D R, Yamabe H.
Membranoproliferative glomerulonephritis associated with hepatitis C virus infection.
N Engl J Med.
1993;
328
465-470
- 13
Kalinke D U, Wüthrich B.
Purpura pigmentosa progressiva bei Kryoglobulinämie Typ III und Tartrazinintoleranz.
Hautarzt.
1999;
50
47-51
- 14
Khella S L, Frost S, Hermann G A, Leventhal L, Whyatt S, Sajid M A, Scherer S S.
Hepatitis C infection, cryoglobulinemia, and vasculitic neuropathy. Treatment with
interferon-alfa.
Neurology.
1995;
45
407-411
- 15
Krengel S, Tebbe B, Goerdt S, Stöffler-Meilicke M, Orfanos C E.
Hepatitis-C-Virus-assoziierte Dermatosen.
Hautarzt.
1999;
50
629-636
- 16
Landthaler M.
Die Kryoproteinämie.
Hautarzt.
1980;
31
633-638
- 17
Levey J M, Björnsson B, Banner B.
Mixed cryoglobulinemia in chronic hepatitis C infection: a clinicopathological analysis
of 10 cases and review of recent literature.
Medicine.
1994;
73
53-67
- 18
Marcellin P, Descamps V, Martinot-Peignoux M.
Cryoglobulinemia with vasculitis associated with hepatitis C infection.
Gastroenterology.
1993;
104
272-277
- 19
Misiani R, Bellavita P, Baio P, Caldara R, Ferruzzi S, Rossi P, Tengattini F.
Successful treatment of HCV-associated cryoglobulinaemic glomerulonephritis with a
combination of interferon-alpha and ribavirin.
Nephrol Dial Transplant.
1999;
14
1558-1560
- 20
Pakula A S, Garden J M, Roth S I.
Cryoglobulinemia and cutaneous leukocytoclastic vasculitis associated with hepatitis
C virus infection.
J Am Acad Dermatol.
1993;
28
850-854
- 21 Papaevangelou G, Roumeliotou A, Kotsianopoulou M.
Sexual transmission of HCV. In: Hollinger FB, Lemon SM, Margolis H (Hrsg) Viral hepatitis and liver disease. Baltimore;
Williams and Wilkins 1991
- 22
Pawlotsky J-M, Yahia M B, Andre C, Voisin M-C, Intrator L.
Immunological disorders in C virus chronic active hepatitis: a prospective case-control
study.
Hepatology.
1994;
91
841-848
- 23
Pawlotsky J-M, Dhumeaux D, Bagot M.
Hepatitis C virus in dermatology - a review.
Arch Dermatol.
1995;
131
1185-1193
- 24
Robert-Koch-Institut .
Merkblatt für Ärzte. Hepatitis C.
Arzneimitteltherapie.
2000;
18
121-124
- 25
Smith B, Shenefelt P D, Soto O, Valeriano J.
Pyoderma gangrenosum in patient with cryoglobulinemia and hepatitis C successfully
treated with interferon alfa.
J Am Acad Dermatol.
1996;
34
901-903
- 26
Stölzel U, Köstler E, Koszka G.
Low prevalence of hepatitis C virus infection of porphyria cutanea tarda in Germany.
Hepatology.
1995;
21
1500-1503
- 27
Trepo C, Zuckerman A J, Bird R C, Prince A M.
The role of circulating hepatitis B antigen/antibody immune complexes in the pathogenesis
of vascular and hepatic manifestations in polyarteritis nodosa.
J Clin Pathol.
1974;
27
863-864
- 28
Willson R A.
Extrahepatic manifestations of chronic viral hepatitis.
Am J Gastroenterol.
1997;
92
4-17
- 29
Zeuzem S, Roth W K, Hermann G.
Virushepatitis C.
Z Gastroenterol.
1995;
33
117-132
Dr. G. Wagner
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