Sinonasal Non-Hodgkin's Lymphoma with Skull Base Involvement

Amos O. Dare; Rajiv V. Datta; Thom R. Loree; Wesley L. Hicks Jr; Walter Grand

doi:10.1055/s-2001-14433

Skull Base, Table of Contents

Skull Base 2001; 11(2): 129-136
DOI: 10.1055/s-2001-14433

CASE REPORTS

Sinonasal Non-Hodgkin's Lymphoma with Skull Base Involvement

Amos O. Dare¹ , Rajiv V. Datta² , Thom R. Loree² , Wesley L. Hicks, Jr.² , Walter Grand¹

¹Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York
²Head and Neck Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York

Abstract

ABSTRACT

Non-Hodgkin's lymphoma (NHL) is a rare tumor of the skull base. As the incidence of primary central nervous system (CNS) lymphoma has increased, atypical presentations involving the skull or cranial base exclusively have been reported. In immunocompetent patients with no previous history or predisposing factors, the diagnosis of primary NHL of the skull base may be delayed. We present four cases of nasal and paranasal sinus NHL with both skull base and intracranial involvement in immunocompetent patients. Clinicopathologic correlation suggests that cranial base and intracranial involvement with NHL represents advanced-stage primary sinonasal disease. Surgical biopsy before definitive treatment is recommended. Radiation therapy provides local control; adjuvant chemotherapy after primary radiation therapy may be required for recurrent disease.

KEYWORD

Lymphoma - skull base - paranasal

Full Text

References

REFERENCES

1 De Pena C A, van Tassel P, Lee Y. Lymphoma of the head and neck. Radiol Clin North Am . 1990; 28 723-743
2 Evans C. A review of non-Hodgkin's lymphomata of the head and neck. Clin Oncol. 1981; 7 23-31
3 Eby N L, Grufferman S, Flannelly C M. Increasing incidence of primary brain lymphoma in the US. Cancer. 1988; 62 2461-2465
4 Werner M H, Phuphanich S, Lyman G H. The increasing incidence of malignant gliomas and primary central nervous system lymphoma in the elderly. Cancer. 1995; 76 1634-1642
5 Roman-Goldstein S M, Jones A, Delashaw J B. Atypical central nervous lymphoma at the cranial base: report of four cases. Neurosurgery. 1998; 43 614-616
6 Duncavage J A, Campbell B H, Hanson G A. Diagnosis of malignant lymphomas of the nasal cavity, paranasal sinuses and nasopharynx. Laryngoscope. 1983; 93 1276-1280
7 Jacobs C, Hoppe R T. Non-Hodgkin's lymphomas of the head and neck extranodal sites. Int J Radiat Oncol Biol Phys. 1985; 11 357-364
8 Batsakis J G. Tumors of the head and neck: clinical and pathological considerations 2nd ed. Baltimore, MD: Williams & Wilkins 1979 : 450-491
9 Harnsberger R H, Bragg D G, Osborn A G. Non-Hodgkin's lymphoma of the head and neck: CT evaluation of nodal and extranodal sites. AJR AM J Roentgenol. 1987; 179 785-791
10 Shima N, Kobashi Y, Tsutsui K. Extranodal non-Hodgkin's lymphoma of the head and neck. <~>A clinicopathologic study in the Kyoto-Nara area in Japan. Cancer. 1990; 66 1190-1197
11 Han M H, Chang K H, Kim I O. Non-Hodgkin lymphoma of the central skull base: MR manifestations. J Comput Assist Tomogr. 1993; 17 567-571
12 Kieserman S P, Finn D G. Non-Hodgkin's lymphoma of the external auditory canal in an HIV-positive patient. J Laryngol Otol. 1995; 109 751-754
13 Oyama H, Nagane M, Shibui S. Skull base malignant lymphoma: a case report and review of the literature. Jpn J Clin Oncol. 1992; 22 131-135
14 Yang P J, Carmody R F, Seeger J F. Computed tomography in hematologic malignancies of paranasal sinuses. J Comput Assist Tomogr. 1986; 10 1003-1005
15 Erlich R B, Swerdlow S H, Gupta N K, Lister J. Primary lymphoma of the skull presenting as multiple cranial nerve palsies. Leuk Lymphoma. 1996; 23 395-399
16 Koh C S, Tan C T, Alhady S F. Cavernous sinus syndrome. A manifestation of non-Hodgkin's lymphoma of the ethmoid sinus. Med J Aust. 1983; 29 451-452
17 Shibata M, Shimoda M, Sato O. A case of bilateral panophthalmoplegia caused by paranasal malignant lymphoma extending into the skull base [article in Japanese]. No Shinkei Geka. 1992; 20 717-721
18 Hausdorff J, Davis E, Long G. Non-Hodgkin's lymphoma of the paranasal sinuses: clinical and pathological features, and response to combined-modality therapy. Cancer J Sci Am . 1997; 3 303-311
19 Logsdon M D, Ha C S, Kavadi V S. Lymphoma of the nasal cavity and paranasal sinuses. Cancer. 1997; 80 477-488
20 Tran L M, Mark R, Fu Y S. Primary non-Hodgkin's lymphomas of the paranasal sinuses and nasal cavity. Am J Clin Oncol. 1992; 15 222-225
21 Artese L, Di Alberti L, Lombardo M. Head and neck non-Hodgkin's lymphomas. Eur J Cancer Oral Oncol . 1995; 31B 299-300
22 Economopoulos T, Fountzilas G, Kostourou A. Primary extranodal non-Hodgkin's lymphoma of the head and neck adults: a clinicopathological comparison between tonsillar and non-tonsillar lymphomas. Anticancer Res . 1998; 18 4655-4660
23 Jacobs C, Weiss L, Hoppe R T. The management of extranodal head and neck lymphomas. Arch Otolaryngol Head Neck Surg . 1986; 112 654-658