Die nichtinvasive Bestimmung der Dimensionen peripherer Lungenstrukturen mittels Aerosolmorphometrie: Kenntnisstand und Perspektiven

Literatur

• 1 American Thoracic Society . Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease.  Am J Respir Crit Care Med. 1995;  152 S77-S120
• 2 Beinert T, Brand P, Behr J, Vogelmeier C, Heyder J. Peripheral airspace dimensions in patients with COPD.  Chest. 1995;  108 998-1003
• 3 Beinert T, Brand P, Nitschke J, Schulz H, Heyder J, Behr M, Schwaibelmaier M, Hettich R, Fruhmann G. Periphere Atemwegsgeometrie bei Patienten mit Bronchialobstruktion unterschiedlicher Pathogenese.  Atemw- und Lungenkr. 1991;  17 194 (Abstract)
• 4 Bennett W D, Smaldone G C. Use of aerosols to estimate mean air-space size in chronic obstructive pulmonary disease.  J Appl Physiol. 1988;  64 1554-1560
• 5 Blanchard J D, Heyder J, O'Donnell C R, Brain J D. Aerosol derived lung morphometry: comparisons with a lung model and lung function indexes.  J Appl Physiol. 1991;  71 1216-1224
• 6 Brand P, Beinert T, Fruhmann G, Hillebrecht A, Heyder J. Aerosol derived airway morphometry at different levels of lung infiltration.  J Aerosol Med. 1993;  6 165-176
• 7 Brand P, Selzer T, Tuch T, Schulz A, Heyder J. Accuracy and resolution power of aerosol derived airway morphometry in a simple lung model.  Experimental Lung Research. 1994;  20 185-205
• 8 Brand P, Rieger C, Beinert T, Heyder J. Aerosol derived airway morphometry in healthy subjects.  Eur Respir J. 1995;  8 1639-1646
• 9 Brand P, Kohlhäufl M, Meyer T, Selzer T, Heyder J, Häußinger K. Aerosol derived airway morphometry and aerosol bolus dispersion in patients with lung fibrosis and lung emphysema.  Chest. 1999;  116 543-548
• 10 Haefeli-Bleuer B, Weibel E. Morphometry of the human pulmonary acinus.  Anat Rec. 1988;  220 401-414
• 11 Hankinson J L, Palmes E D, Lapp N L. Pulmonary air space size in coal miners.  Amer Rev Respir Dis. 1979;  129 391-397
• 12 Heyder J. Gravitational deposition of aerosol particles within a system of randomly orientated tubes.  J Aerosol Sci. 1975;  6 133-137
• 13 Heyder J. Charting human thoracic airways by aerosols.  Clin Phys Physiol Meas. 1983;  4 29-37
• 14 Heyder J. Assessment of airway geometry with inert aerosols.  J Aerosols Med. 1989;  2 89-97
• 15 Kohlhäufl M, Brand P, Selzer T, Scheuch G, Meyer Th, Weber N, Schulz H, Häußinger K, Heyder J. Diagnosis of emphysema in patíents with chronic bronchitis: a new approach.  Eur Respir J. 1998;  12 793-798
• 16 Kohlhäufl M, Brand P, Häußinger K, Scheuch G, Schulz H, Heyder J. Pneumologische Diagnostik mit Modellaerosolen - 1. Teil: Intrapulmonale Morphometrie.  Pneumologie. 1997;  51 40-46
• 17 Kohlhäufl M, Brand P, Rock C, Radons T, Scheuch D, Meyer Th, Weber N, Schulz H, Pfeifer K J, Häußinger K, Heyder J. Noninvasive diagnosis of emphysema.  Am J Respir Crit Care Med. 1999;  160 913-918
• 18 Kohlhäufl M, Brand P, Scheuch G, Meyer Th, Schulz H, Häussinger K, Heyder J. Aerosol morphometry and aerosol bolus dispersion in patients with CT-determined combined pulmonary emphysema and lung fibrosis.  J Aerosol Med. 2000;  13 117-124
• 19 Lehnigk B, Schleiss M, Bluhme P, Jörres R, Brand P, Heyder J, Magnussen M. Aerosol-derived effective air space diameter (EAD) in different types of emphysema as characterized by computer tomography compared to healthy subjects.  J Aerosol Med. 1995;  8 126 (Abstract)
• 20 Lehnigk B, Schleiss M, Bluhme P, Jörres R, Brand P, Heyder J, Magnussen H. Aerosol derived airway morphometry in emphysema and fibrosis.  Am J Respir Crit Care Med. 1995;  151 118-(Abstract)
• 21 Lehnigk B, Schleiss M, Becker C, Jörres R, Brand P, Heyder J, Magnussen H. Intraindividual variability of aerosol-derived effective airway diameter (EAD) in healthy subjects and patients with emphysema.  ERJ. 1996;  9 Suppl. 23 471s (Abstract)
• 22 Morgan M DL, Denison D M, Strickland B. Value of computed tomography for selecting patients with bullous lung disease for surgery.  Thorax. 1986;  41 855-862
• 23 Nikiforov A I, Lippmann M, Palmes E D. Validation of an in vivo aerosol probe technique by measurement of deposition and morphometry in exised human lungs.  Ann Occup Hyg. 1988;  32 33-39
• 24 Palmes E D, Altshuler B, Nelson N. Deposition of aerosols in the human respiratory tract during breath holding. In: Davis CN (ed.). Inhaled particles and vapors Pergamon press 1967: 339
• 25 Palmes E D, Wang C S, Goldring R M, Altshuler B. Effect of depth of inhalation on aerosol persistence during breath holding.  J Appl Physiol. 1973;  34 356
• 26 Pride N B, Barter C E, Hugh-Jonesw P. The ventilation of bullae and the effect of their removal on thoracic gas volumes and test of over-all pulmonary function.  Am Rev Respir Dis. 1973;  107 83-89
• 27 Rosenthal F S. Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema.  J Appl Physiol. 1995;  78 1585-1595
• 28 Rosenthal F S. Aerosol recovery following breathholding derived from the distribution of chordlength in pulmonary tissue.  J Aerosol Sci. 1989;  20 267-277
• 29 Sakai F, Gamsu J G, Ray C S. Pulmonary function abnormalities in patients with CT-determined emphysema.  J Comput Assist Tomogr. 1987;  11 963-968
• 30 Scheuch G, Schiller-Scotland C F, Stahlhofen W. The effect of particle size on the evaluation of aerosol-derived effective airway dimension (EAD).  J Aerosol Med. 1992;  5 1-9
• 31 Siekmeier R, Lintl H, Stahlhofen W, Kronenberger H, Meyer-Sydow J, Schultze-Werninghaus G, Heyder J. Morphometrischer Nachweis einer pharmakologisch induzierten Bronchokonstriktion/Bronchodilatation mit einer neuen Aerosolmethode.  Atemw-Lungenkr. 1989;  15 319-321
• 32 Stahlhofen W, Gebhardt J, Heyder J. Experimental determination of regional deposition of aerosol particles in the human respiratory tract.  Am Ind Hyg Assoc J. 1980;  41 385-398
• 33 Thurlbeck W M. The internal surface area of nonemphysematous lungs.  Am Rev Respir Dis. 1967;  95 765-773
• 34 Thurlbeck W M. Quantitative anatomy of the lung. In: Thurlbeck WM, Churg AM (eds.). Pathology of the lung Stuttgart: Thieme Verlag 1995
• 35 Vogt-Ladner G, Schmid M, Hartmann R, Worth H. Change of effective air space diameters of patients with COPD - Aerosol bolus technique versus indices of computer tomography.  Eur Respir J. 1997;  10 (Suppl. 25) 247s-(Abstract)
• 36 Vogt-Ladner G, Schmid M, Hartmann R, Worth H. In vivo Diagnostik des Lungenemphysems - Vergleich neuerer lungenfunktionsanalytischer Kenngrößen (Mischluftindex, Dispersion und Morphometrie monodisperser Aerosole) mit der Computertomographie in einer Längsschnittuntersuchung.  Pneumologie. 1997;  51 658 (Abstract)
• 37 Weibel E R. Morphometry of the human lung. New York: Academic Press Inc 1963
• 38 Worth H, Vogt-Ladner G, Hartmann R, Schmid M. Variability of routine lung function indices, CO₂ exspirograms and morphometry by monodisperse aerosols for the diagnosis of pulmonary emphysema.  Am J Respir Crit Care Med. 1999;  159 809 (Abstract)
• 39 Worth H, Vogt-Ladner G, Hartmann R, Schmid M. A long term follow up of routine lung function indices, analysis of CO₂ exspirograms and monodisperse aerosol bolus technique for the diagnosis of pulmonary emphysema.  Eur Respir J. 1998;  12 (Suppl. 28) 52s (Abstract)
• 40 Zeman K L, Mascarella J J, Bennett W D. Abnormal effective airway diameters (EADs) associated with COPD are related to impaired pulmonary function.  J Aerosol Med. 1995;  8 A126 (Abstract)