J Reconstr Microsurg 2001; 17(5): 357-362
DOI: 10.1055/s-2001-16028

Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Enhanced Reinnervation of the Paralyzed Orbicularis Oculi Muscle after Insulin-like Growth Factor-I (IGF-I) Delivery to a Nerve Graft

Panayotis K. Thanos1 2 , David A. Tiangco3 , Julia K. Terzis3
  • 1Department of Neuroscience, State University of New York at Stony Brook, NY
  • 2Center for Imaging and Neuroscience, Department of Medicine, Brookhaven National Laboratory, Upton, New York
  • 3 Microsurgical Research Center, Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia
Further Information

Publication History

Publication Date:
31 December 2001 (online)


Facial paralysis (FP) remains today one of the most disturbing cranial nerve disorders. The present study utilized the rat model of FP and examined a dual approach of combining the current microsurgical treatment of cross-facial nerve graft (CFNG) with local administration of insulin-like growth factor-I (IGF-I). The efficacy of this combined treatment approach was assessed by motor end-plate analysis of the reinnervated orbicularis oculi muscle (OOM). Local administration of IGF-I (50 μg/ml) to the CFNG demonstrated a 61 percent increase in the number of end-plates in the reinnervated OOMs, compared to the OOMs reinnervated with CFNG plus vehicle. These results indicate that the local therapeutic augmentation of IGF-I levels at the coaptation site(s) of the CFNG may, in fact, enhance reinnervation of muscle and recovery of function in general.