One-Step Synthesis of 2-Phosphonothiolanes by a New Pummerer-Phosphorylation Reaction: Stereoselective S-Oxidation

Abstract

A new one-pot Pummerer phosphorylation reaction allowed an efficient synthesis of 2-phosphonothiolanes starting from thiolane S-oxide and trialkyl phosphites. The S-oxidation of these cyclic sulfides occurred with a total trans-stereoselectivity.

Pummerer reaction - phosphorylation - phosphonothiolanes - sulfoxides - diastereoselectivity

References

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