Vasorelaxing and Antioxidant Constituents from Hernandia nymphaeifolia

Jih-Jung Chen; Ya-Ling Chang; Che-Ming Teng; Ih-Sheng Chen

doi:10.1055/s-2001-17348

Planta Medica, Inhaltsverzeichnis

Planta Med 2001; 67(7): 593-598
DOI: 10.1055/s-2001-17348

Original Paper

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Vasorelaxing and Antioxidant Constituents from Hernandia nymphaeifolia

Jih-Jung Chen¹ , Ya-Ling Chang² , Che-Ming Teng² , Ih-Sheng Chen^3,*

¹ Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
² Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
³ Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Abstract

Three new alkaloids, (+)-nymphaedaline (1), oxo-O-methylbulbocapnine (2), and (+)-laetine (3), have been isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these new compounds were elucidated by spectroscopic analysis. Among the isolates of this plant obtained till now, sixteen compounds show effective inhibitory activities on the contraction of vascular smooth muscles induced by high K⁺ (80 mM) or norepinephrine (3 μM). In addition, eight compounds showed effective antioxidant activities in scavenging the stable free radical, diphenyl-picryl-hydrazyl (DPPH).

Key words

Hernandia nymphaeifolia - Hernandiaceae - alkaloids - benzylisoquinoline-benzaldehyde dimer - nymphaedaline - aporphine - oxo-O-methylbulbocapnine - (+)-laetine - vasorelaxing activity - antioxidant activity

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Referenzen

References

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Prof. Dr I. S. Chen

Graduate Institute of Pharmaceutical Sciences

Kaohsiung Medical University

Kaohsiung

Taiwan

Republic of China

eMail: m635013@cc.kmu.edu.tw

Fax: +886-7-3210683