Long-Term Correction of Hyperglycaemia in Streptozotocin-Induced Diabetic Rats Transplanted with Islets Placed in an Implantation Device

Introduction

Pancreatic islet xenotransplantation might conceivably be successfully achieved if the islets are placed in a device protecting them against immune rejection [1]. We were interested in taking a first step in exploring this possibility using a rat model. The present study was aimed at monitoring the changes in body weight and glycemia occurring in streptozotocin-induced diabetic rats (STZ rats) transplanted with xenografted islets. Islets were prepared from animals of the same species and strain and placed in an implantation device with selectively permeable membranes.

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