Synthesis and Properties of β-Cyanovinyl Polyhaloalkyl Ketones

Abstract

A number of β-cyanovinyl polyhaloalkyl ketones were prepared by the reaction of readily accessible 2-ethoxy-4-trimethylsiloxy-4-polyhaloalkylbut-3-ene nitriles with sulfuric acid. It was demonstrated, that β-cyanovinyl trifluoromethyl ketone, are useful fluorinated building blocks susceptible to 1,2- and 1,4-addition reactions.

eliminations - α,β-unsaturated ketones - fluorinated compounds - cycloadditions - heterocycles

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