Cytotoxic Sesquiterpene Lactones from Carpesium abrotanoides

Jun Sung Lee; Byung Sun Min; Sang Myung Lee; Min Kyun Na; Byung Mok Kwon; Chong Ock Lee; Young Ho Kim; Ki Hwan Bae

doi:10.1055/s-2002-33789

Planta Med 2002; 68(8): 745-747
DOI: 10.1055/s-2002-33789

Letter

Cytotoxic Sesquiterpene Lactones from Carpesium abrotanoides

JunSung Lee¹ , ByungSun Min² , SangMyung Lee² , MinKyun Na¹ , ByungMok Kwon² , ChongOck Lee³ , YoungHo Kim¹ , KiHwan Bae¹

¹College of Pharmacy, Chungnam National University, Taejon, Korea
²Korea Research Institute of Bioscience & Biotechnology, Taejon, Korea
³Korea Research Institute of Chemical Technology, Teajon, Korea

Abstract

Eight sesquiterpene lactones, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED₅₀ values, < 20 μM) against all tumor call lines tested. Among these compounds, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED₅₀, < 10 μM) comparable to that of cisplatin.

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Prof. KiHwan Bae

College of Pharmacy

Chungnam National University

Taejon 305-764

Korea

Email: baekh@cnu.ac.kr

Fax: +82-42-823-6566