Abstract
Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC50 values of 19.1 ± 3.6 and 3.81 ± 0.5 μM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC50 = 23.4 ± 1.5 μM). Compounds 2 and 4 showed hepatoprotective effects with EC50 values of 10.3 ± 0.42 and 32.3 ± 2.62 μM, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
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Prof. Dr. Youn-Chul Kim
MRRC and College of Pharmacy
Wonkwang University
Iksan 570-749
South Korea
Email: yckim@wonkwang.ac.kr
Fax: +82-63-852-8837
