An Isorhapontigenin Tetramer and a Novel Stilbene Dimer from Gnetum hainanense

Abstract

The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further supported by X-ray crystallographic analysis. The anti-inflammatory activity of 1 has been tested, and it showed potent activity of histamine receptor antagonism.

Gnetum hainanense - Gnetaceae - anti-histaminic - isorhapontigenin tetramer - gnetuhainin R - gnetuhainin S

References

• 1 Huang K -S, Wang Y -H, Li R -L, Lin M. Five new stilbene dimers from the lianas of Gnetum hainanense .  J Nat Prod. 2000;  63 86-9
• 2 Huang K -S, Wang Y -H, Li R -L, Lin M. Stilbene dimers from the lianas of Gnetum hainanense .  Phytochemistry. 2000;  54 875-81
• 3 Wang Y -H, Huang K -S, Lin M. Four new stilbene dimers from the lianas of Gnetum hainanense .  JANPR. 2001;  3 169-76
• 4 Wang Y -H, Huang K -S, Li R -L, Lin M. Gnetuhainin P, a new isorhapontigenin dimer from the Lianas of Gnetum hainanense .  Chin Chem Lett. 2000;  11 1061
• 5 Huang K -S, Li R -L, Wang Y -H, Lin M. Three new stilbene trimers from the lianas of Gnetum hainanense .  Planta Med. 2001;  67 61-4
• 6 Siddiqui Z S, Rahman M, Khan M A, Zaman A, Lavaud C, Masssiot G . et al . Gnetulin, a dimer of 3′,4,5′-trihydroxy-3-methoxystilbene from Gnetum ula .  Tetrahedron. 1993;  49 10 393-6
• 7 Ducrot P -H, Kollmann A, Bala A -E, Magina A, Kerhoas L, Dolorme R, Einhorn J. Cyphostemmins A-B, two new antifungal oligostilbenes from Cyphostemma crotalatioides ( Vitaceae ).  Tetrahedron Lett. 1998;  39 9655-8
• 8 Yang D -X, He K -Q, Cheng G -F. Effect of tremulacin on actions of SRS-A and histamine.  Acta Pharm Sin. 1995;  30 254-7