Evidence for a Positive Association Between Pulmonary Function and Wine Intake in a Population-Based Study

Holger J. Schünemann; Brydon J. B. Grant; Jo L. Freudenheim; Paola Muti; Susan E. McCann; Deepa Kudalkar; Malathi Ram; Tom Nochajski; Marcia Russell; Maurizio Trevisan

doi:10.1055/s-2002-36527

Sleep Breath 2002; 06(4): 161-174
DOI: 10.1055/s-2002-36527

ORIGINAL ARTICLE

Evidence for a Positive Association Between Pulmonary Function and Wine Intake in a Population-Based Study

Holger J. Schünemann^1,2 , Brydon J.B. Grant^1,2,3,4 , Jo L. Freudenheim² , Paola Muti² , Susan E. McCann² , Deepa Kudalkar¹ , Malathi Ram² , Tom Nochajski⁵ , Marcia Russell⁶ , Maurizio Trevisan²

¹Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York
²Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York
³Department of Physiology and Biophysics; School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York
⁴Section of Pulmonary, Critical Care, and Sleep Medicine, Veterans Administration Medical Center, Buffalo, New York
⁵Research Institute on Addictions, Buffalo, New York
⁶Prevention Research Center, Berkeley, California

Abstract

ABSTRACT

Background: Lung function is a strong predictor of cardiovascular and all-cause mortality. Previous studies suggest that alcohol exposure may be linked to impaired pulmonary function through oxidant-antioxidant mechanisms. Alcoholic beverages may be an important source of oxidants and antioxidants. We analyzed the relation of beverage-specific alcohol intake with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in a random sample of 1555 residents of Western New York, USA. Methods: We expressed pulmonary function as percent of predicted normal FEV1 (FEV1%) and FVC (FVC%) after adjustment for height, age, gender, and race. To obtain information on alcohol intake we used a questionnaire that reliably queries total alcohol and beverage-specific recent (past 30 days) and lifetime alcohol consumption. Results: Using multiple linear regression analysis after adjustment for covariates (pack-years of smoking, weight, smoking status, education, nutritional factors, and for FEV1%, in addition, eosinophil count), we observed no significant correlation between total alcohol intake and lung function. However, we found positive associations of recent and lifetime wine intake with FEV1% and FVC%. When we analyzed white and red wine intake separately, the association of lung function with red wine was weaker than with white wine. Conclusion: While total alcohol intake was not related to lung function, wine intake showed a positive association with lung function. Although we cannot exclude residual confounding by healthier lifestyle in wine drinkers, differential effects of alcoholic beverages on lung health may exist.

KEYWORD

Lung function - airway obstruction - alcohol - FEV1 - wine

Full Text

References

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