Bicyclic Aminoalkyl N-Heterocycles by Ring-Chain-Transformation of Bridged­ 1,3-Dicarbonyl Heteroanalogues with Aminopyrazoles and Aminotriazole­

Magdalena Karanik; Michael Pätzel; Jürgen Liebscher

doi:10.1055/s-2003-39402

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Bicyclic Aminoalkyl N-Heterocycles by Ring-Chain-Transformation of Bridged 1,3-Dicarbonyl Heteroanalogues with Aminopyrazoles and Aminotriazole

Magdalena Karanik^a,b, Michael Pätzel^a, Jürgen Liebscher*^a
^a Institut für Chemie, Humboldt-Universität Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Germany
Fax: +49(30)20937552; e-Mail: liebscher@chemie.hu-berlin.de;
^b Technical University of Szczecin, Institute of Fundamental Chemistry, Al. Piastow 42, 71-065 Szczecin, Poland

Abstract

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Abstract

Reaction of cyclic iminium salts 3 as 1,3-dicarbonyl heteroanalogues with 2-aminoazoles 4 affords bicyclic ω-aminoalkyl N-heterocycles 7 and 11 in a straightforward one-step procedure by a ring-chain-transformation reaction. These products are analogues of interesting pharmaceutical compounds.

Key words

heterocycles - ring closure - ring opening - imines - amines

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References

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Bicyclic Aminoalkyl N-Heterocycles by Ring-Chain-Transformation of Bridged­ 1,3-Dicarbonyl Heteroanalogues with Aminopyrazoles and Aminotriazole­

Bicyclic Aminoalkyl N-Heterocycles by Ring-Chain-Transformation of Bridged 1,3-Dicarbonyl Heteroanalogues with Aminopyrazoles and Aminotriazole