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Synthesis 2003(13): 1995-2000
DOI: 10.1055/s-2003-41042
PAPER
© Georg Thieme Verlag Stuttgart · New York

Molecular Diversity of Tonghaosu: Synthesis of Lactam-Containing Tonghaosu Analogs

Biao-Lin Yin, Zheng-Min Yang, Tai-Shan Hu, Yu-Lin Wu*
State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China
e-Mail: ylwu@mail.sioc.ac.cn;
Further Information

Publication History

Received 13 May 2003
Publication Date:
28 August 2003 (online)

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Abstract

A new type of tonghaosu analogs containing spiroketal and lactam functionality was synthesized from methyl 2-furoate and amino alcohols. The stereoselective control of spiroketal chirality was also explored.

Key words

tonghaosu analogs - antifeedant - lactam - spiroketalization - diastereoselective

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