Involvement of 5-HT2 Receptor in Imipramine-Induced Hyperglycemia in Mice

Y. Sugimoto; K. Inoue; J. Yamada

doi:10.1055/s-2003-42650

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2003; 35(9): 511-516
DOI: 10.1055/s-2003-42650

Original Basic

Involvement of 5-HT₂ Receptor in Imipramine-Induced Hyperglycemia in Mice

Y. Sugimoto¹ , K. Inoue¹ , J. Yamada¹

¹Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe, Japan

Abstract

Effects of imipramine on plasma glucose levels were investigated in mice. Imipramine i. p. induced dose-dependent hyperglycemia, which was enhanced by pretreatment with 5-HT_1/2/5/7 receptor antagonist methysergide and 5-HT_2A/2B/2C receptor antagonist LY 53 857. 5-HT_2C/2B receptor antagonist SB 206 553 also augmented imipramine-induced hyperglycemia although 5-HT_1A and 5-HT_1B receptor antagonist (-)-propranolol,5-HT_2A receptor antagonist ketanserin and 5-HT_3/4 receptor antagonist tropisetron each had no effect. Imipramine i. p.-induced hyperglycemia was antagonized by the 5-HT_2C/2B receptor agonist 1-(3-chlorophenyl)piperazine (mCPP), while the 5-HT_2B receptor agonist BW 723C86 had no effect. Intracerebroventricular injection of imipramine also elevated plasma glucose levels, which is enhanced by SB 206 553. Hyperglycemia elicited by central injection of imipramine was abolished by adrenalectomy. These results suggest that imipramine-induced hyperglycemia in mice is related to its inhibition of the central 5-HT_2C receptor. Moreover, our results indicate that adrenaline release is related to imipramine-induced hyperglycemia.

Key words

Imipramine - 5-HT (5-hydroxytryptamine, serotonin) - 5-HT_2C/2B Receptor - Glucose - Antidepressants

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References

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Y. Sugimoto

Department of Pharmacology · Kobe Pharmaceutical University

Motoyamakita-machi · Higashinada-ku · Kobe 658-8558 · Japan

Telefon: +81(78)441-7573

Fax: +81(78)441-7574 ·

eMail: yumisugi@kobepharma-u.ac.jp