Abstract
Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β-hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β-hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC)
of 6.25 μg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 μg/mL). Both compounds expressed moderate cytotoxic activity
towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCl-H187
(small cell lung cancer) cell lines.
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Dr. Pakawan Nongkunsarn
Department of Chemistry
Faculty of Science
Chiang Mai University
Chiang Mai 50200
Thailand
Fax: +66-5389-2277
Email: pakawan@science.cmu.ac.th
