Planta Med 2003; 69(10): 914-920
DOI: 10.1055/s-2003-45100
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Antitussive Activity of Stemona Alkaloids from Stemona tuberosa

Hoi-Sing Chung1 , Po-Ming Hon2 , Ge Lin1 , Paul Pui-Hay But2 , Hui Dong2
  • 1Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
  • 2Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
This work was supported by Industry Support Fund (Reference No. AF/281/97) from Hong Kong Industry Department
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Received: February 18, 2003

Accepted: May 24, 2003

02. Dezember 2003 (online)


Bioactivity-directed fractionation of the crude extract of Stemona tuberosa led to the isolation and characterization of four new stenine-type Stemona alkaloids, namely tuberostemonine J (2), tuberostemonine H (3), epi-bisdehydrotuberostemonine J (4) and neostenine (5), together with the known neotuberostemonine (1). These five isolated alkaloids were examined for antitussive activity in guinea pig after cough induction by citric acid aerosol stimulation. In this report, we demonstrated, for the first time, that compounds 1 and 5 showed significant antitussive activities. Further study of the structure-activity relationship on these isolated alkaloids and two synthetic analogues revealed that the saturated tricyclic pyrrolo[3,2,1-jk][1]benzazepine nucleus is the primary key structure contributing to the antitussive activity and all cis configurations at the three ring junctions are the optimal structure for the antitussive activity of stenine-type Stemona alkaloids.


  • 1 Pilli R A, Ferreira de O liveira, MdC. Recent progress in the chemistry of the Stemona alkaloids.  Nat Prod Rep. 2000;  17 117-27

Prof. Dr. Ge Lin

Department of Pharmacology

Faculty of Medicine

The Chinese University of Hong Kong

Shatin, N. T.

Hong Kong SAR

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