Background: Alterations in AMPA and kainate receptor binding have been revealed in post-mortem
schizophrenic brains. As most patients had been treated with antipsychotics, medication
effects cannot be excluded as a possible explanation for these results. Methods: Within the framework of this animal study, we investigated [3H]AMPA and [3H]kainate receptor binding in different rat brain regions following 6 months of oral
treatment with either haloperidol (1.5 mg/kg/day) or clozapine (45 mg/kg/day). Results: AMPA receptor binding was increased after haloperidol treatment in the striatum,
nucleus accumbens, cingulate cortex, and insular cortex. Clozapine showed increased
AMPA receptor binding only in the anterior cingulate cortex. Kainate receptor binding
was increased by both drugs in all hippocampal subfields. Conclusions: This altered receptor binding may be related to beneficial neuroleptic effects and
side effects. Furthermore, neuroleptic therapy may contribute to some of the post-mortem
findings in the striatum in schizophrenia.
Key words
Haloperidol - clozapine - glutamate receptor - AMPA - kainate
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