Abstract
Weight gain is frequent after smoking cessation, and may limit patient’s will to quit
and long-term success. Nicotine and bupropion are effective drugs for smoking withdrawal.
However, their influence on weight gain, insulin resistance and other cardiovascular
risk factors, as well as possible differences in obese and lean subjects, have not
been fully evaluated. We randomised 25 lean and 25 obese smokers to receive either
bupropion or nicotine patches. Clinical evaluation and lipid profile were performed
at baseline and after treatment. Insulin resistance was also assessed at the end.
Weight, BMI, waist-to-hip ratio, and diastolic blood pressure increased (p < 0.005),
whereas lipid profile improved (p < 0.001) after smoking cessation independently of
obesity at baseline or drug used. Obese patients had higher insulin resistance at
the end (p < 0.05) regardless of drug used. Weight gain was inversely related to age
(β= - 0.125, R = 0.38, p = 0.046), and insulin resistance was related to obesity at
baseline (β = 0.85, R = 0.46, p = 0.02). In conclusion, weight gain after smoking
cessation is not dependent on obesity or drug taken. A beneficial lipid profile is
achieved after quitting smoking with either bupropion or nicotine patch in both obese
and lean subjects.
Key words
Insulin resistance - Obesity - Lipid profile
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J. I. Botella-Carretero
Department of Endocrinology · Hospital Ramón y Cajal
Carretera de Colmenar 9,100 · Madrid 28034 · Spain
Telefon: +34(91)336-8342
Fax: +34(91)336-9016
eMail: jibotella@hotmail.com
