Synthesis of Nitrated Thienylphosphonates via Michaelis-Arbuzov-Type Rearrangement

Thomas Erker; Norbert Handler

doi:10.1055/s-2004-815978

SHORTPAPER

Synthesis of Nitrated Thienylphosphonates via Michaelis-Arbuzov-Type Rearrangement

Thomas Erker*, Norbert Handler
Institute of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090 Wien, Austria
Fax: +43(1)42779551; e-Mail: thomas.erker@univie.ac.at;

Abstract

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Abstract

A facile, catalyst-free synthesis of diethyl thienylphosphonates under mild conditions without solvent is described. The desired products were obtained, via a Michaelis-Arbuzov-type rearrangement, from various activated thienyl halides by reacting with triethyl phosphite.

Key words

Michaelis-Arbuzov rearrangement - phosphorus - heterocycles - thienylphosphonates - halides

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References

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