Disorders of Sweating

William P. Cheshire; Roy Freeman

doi:10.1055/s-2004-817724

Seminars in Neurology, Inhaltsverzeichnis

Semin Neurol 2003; 23(4): 399-406
DOI: 10.1055/s-2004-817724

Disorders of Sweating

William P. Cheshire¹ , Roy Freeman²

¹Department of Neurology, Mayo Clinic, Jacksonville, Florida
²Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

Abstract

ABSTRACT

The clinical spectrum of sweating disorders includes sudomotor excess and deficiency. Hyperhidrosis is characterized by sweating beyond that required to maintain a constant internal body temperature. Hypohidrosis and anhidrosis are distinguished by a reduced or absent ability to generate sweat for the purpose of evaporative heat dissipation. Whereas hyperhidrosis is usually benign, anhidrosis may predispose to hyperthermia. Either hyperhidrosis or anhidrosis may accompany a more serious underlying disorder. Correct diagnosis depends on determining the anatomical pattern of sweating and localizing the lesion within the autonomic nervous system. Sudomotor deficits may involve the frontal operculum, hypothalamus, brain stem, spinal cord, sympathetic chain ganglia, peripheral nerve, or eccrine sweat glands. Treatments for hyperhidrosis include topical aluminum chloride, oral anticholinergic agents, intradermal botulinum toxin for some localized syndromes, and thoracic ganglionic sympathotomy or sympathectomy for refractory palmar hyperhidrosis.

KEYWORDS

Hyperhidrosis - hypohidrosis - peripheral neuropathies - cholinergic antagonists - botulinum toxin - autoimmune diseases of the nervous system

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Referenzen

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