Abstract
A known isoflavanquinone, abruquinone B (1), and a new derivative, abruquinone G (2), were isolated from the aerial parts of Abrus precatorius. Chemical structures of these compounds were elucidated by spectral analyses. While
1 exhibited antitubercular, antiplasmodial and cytotoxic activities, compound 2 showed mild antiviral and cytotoxic activities.
References
- 1 Chang L C. Chinese Material Medica Dictionary. Vol. 3 Chao-Jen Publisher Taichung;
1981: p 2299
- 2
Kuo S, Chen S, Chen L, Wu J, Wang J, Teng C.
Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the
roots of Abrus precatorius
.
Planta Med.
1995;
61
307-12
- 3
Alessandro L, Franco D, Giovanni Battista M, Deise Lia Barros C, Ivan Leoncio D.
Abruquinones: new natural isoflavanquinones.
Gazz Chem Ital.
1979;
109
9-12
- 4
Chiung-Yun C, Li-Jiau H, Jih-Pyang W, Che-Ming T, Sheng-Chih C, Sheng-Chu K.
Synthesis and anti-platelet, anti-inflammatory and anti-allergic activities of methoxyisoflavanquinone
and related compounds.
Chem Pharm Bull.
2000;
48
964-73
- 5
Collins L, Franzblau S G.
Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening
of compounds against Mycobacterium tuberculosis and Mycobacterium avium
.
Antimicrob Agents Chemother.
1997;
41
1004-9
- 6
Skehan P, Stroreng R, Scudiero D, Monks A, McMahon J, Vestica D. et al .
New colorimetric cytotoxicity assay for anticancer-drug screening.
J Natl Cancer Inst.
1990;
82
1107-12
- 7
Trager W, Jensen J B.
Human malaria parasites in continuous culture.
Science.
1976;
193
673-5
- 8
Desjardins R E, Canfield C J, Haynes J D, Chulay J D.
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.
Antimicrob Agents Chemother.
1979;
16
710-8
Dr. Chutima Limmatvapirat
Department of Pharmaceutical Chemistry
Faculty of Pharmacy
Silpakorn University
Nakorn-Pathom 73000
Thailand
Phone: +66-34-255800 ext. 2125 or 2552
Fax: +66-34-255801
Email: chutima@email.pharm.su.ac.th
