Zusammenfassung
Der Wunsch von Patientinnen nach Organerhalt bzw. konservativen Therapiemöglichkeiten
fordert Alternativen zur Hysterektomie in der Behandlung des symptomatischen Uterus
myomatosus. Myomenukleation, Myomembolisation, symptomatische Therapien u. a. können
solche Therapieoptionen sein. Für jede Patientin, auch bei abgeschlossener Familienplanung,
sollte ein individuelles Behandlungskonzept entwickelt werden, dass sowohl die Vorstellungen
der Patientin als auch die Erfolgsaussichten und Risiken der Behandlungsmethoden des
Uterus myomatosus abwägt und zu einer sinnvollen Therapie führt.
Abstract
Total hysterectomy is considered as gold standard in the treatment of symptomatic
uterine fibroids in women without reproductive wishes. However an increasing number
of patients asked for alternatives to hysterectomy. Myomectomy, endometrial ablation,
hormonal treatment, uterine artery embolization, and supracervical hysterectomy may
be useful in the treatment uterine fibroids in an individual patient.
Schlüsselwörter
Myomenukleation - Myomembolisation - suprazervikale Hysterektomie - Endometriumsablation
Key words
Uterine artery embolization - supracervical hysterectomy - myomectomy - endometrial
ablation
Literatur
- 1
Crosignani P G, Vercellini P, Apolone G, De Giorni O, Cortesi I, Meschia M.
Endometrial resection versus vaginal hysterectomy for menorrhagia: long-term clinical
and quality-of-life outcomes.
Am J Obstet Gynecol.
1997;
177
95-101
- 2
Khastgir G, Studd J.
Patient's outlook, experience, and satisfaction with hysterectomy, bilateral oophorectomy,
and subsequent continuation of hormone replacement therapy.
Am J Obstet Gynecol.
2000;
183
1427-1433
- 3
Farrell S A, Kieser K.
Sexuality after hysterectomy.
Obstet Gynecol.
2000;
95
1045-1051
- 4
Roovers J P, van der Bom J G, van der Vaart C H, Heintz A P.
Hysterectomy and sexual wellbeing: prospective observational study of vaginal hysterectomy,
subtotal abdominal hysterectomy, and total abdominal hysterectomy.
BMJ.
2003;
327
774-778
- 5
Zobbe V, Gimbel H, Andersen B M, Filtenborg T, Jakobson K, Sorensen H C, Toftager-Larsen K,
sidenius K, Moller N, Madsen E, Vejtorp M, Clausen H, Rosgaard A, Gluud C, Ottesen B S,
Tabor A.
Sexuality after total vs. subtotal hysterectomy.
Acta Obstet Gynecol Scand.
2004;
83
191-196
- 6
Helstrom L.
Sexuality after hysterectomy: a model based on quantitative and qualitative analysis
of 104 women before and after subtotal hysterectomy.
J Psychosom Obstet Gynaecol.
1995;
15
219-229
- 7
Thakar R, Ayers S, Clarkson P, Stanton S, Manyonda I.
Outcomes after total versus subtotal abdominal hysterectomy.
N Engl J Med.
2002;
347
1318-1325
- 8
Brown J S, Sawaya G, Thom D H, Grady D.
Hysterectomy and urinary incontinence: a systematic review.
Lancet.
2000;
356
535-539
- 9
Van der Vaart C H, van der Bom J G, De Leeuw J R, Roovers J P, Heintz A P.
The contribution of hysterectomy to the occurence of urge and stress incontinence
symptoms.
BJOG.
2002;
109
149-154
- 10
Kjerulff K H, Langenberg P W, Greenway L, Uman J, Harvey L A.
Urinary incontinence and hysterectomy in large prospective cohort study in American
women.
J Urol.
2002;
167
2088-2092
- 11
Mercorio F, De Simone R, Spiezio Sardo A, Cerrota G, Bifulco G, Vanacore F, Nappi C.
The effect of a levonorgestrel-releasing intrauterine device in the treatment of myoma-related
menorrhagia.
Contraception.
2003;
67
277-280
- 12 Baggish M S. Operative hysteroscopy. In: Thompson ID, Rock JA (eds). Te Linde's
Operative Gynecology. Ed. 8. Lippincott, Philadelphia 1997; 415-445
- 13
Hart R, Magos A.
The alternatives to hysterectomy.
Baillieres Clin Obstet Gynecol.
1999;
13
271-290
- 14
Goldfarb H A.
Combining myoma coagulation with endometrial ablation/resection reduces subsequent
surgery rates.
JSLS.
2001;
5
97-98
- 15
Soysal M E, Syosal S K, Vicdan K.
Thermal Balloon Ablation in Myoma-Induced Menorrhagia under local Anesthesia.
Gyn Obstet Invest.
2001;
51
128-133
- 16
Kettel L M, Murphy A A, Morales A J, Yen S S.
Clinical efficacy of the antiprogesterone RU486 in the treatment of endometriosis
and uterine fibroids.
Hum Reprod.
1994;
9 (Suppl 1)
116-120
- 17
Gocman A, Kara I H, Karaca M.
The effect of add-back therapy with tibolone on myoma uteri.
Clin Exp Obstet Gynecol.
2002;
29
222-224
- 18
Bai S W, Jang J B, Lee D Y, Jeong K A, Kim S K, Park K H.
Uterine artery embolization for the treatment of uterine leiomyomas.
Yonsei Med J.
2002;
43
346-350
- 19
Andersen P E, Lund N, Justesen P, Munk T, Elle B, Floridin C.
Uterine artery embolization of symptomatic uterine fibroids.
Acta Radiologica.
2001;
42
234-238
- 20
Hutchins F L, Worthington-Kirsch R, Berkowitz R P.
Selective uterine artery embolization as primary treatment for symptomativ leiomyomata
uteri.
J Am Assoc Gynecol Laparosc.
1999;
6
279-284
- 21
Goodwin S C, McLucas B, Lee M, Chen G BS, Perrella R, Vedantham S, Muir S, Lai A,
Sayre J W, DeLeon M BS.
Uterine artery embolization for the treamtent of uterine leiomyomata midterm results.
JVIR.
1999;
10
1159-1165
- 22
Siskin G P, Stainken B F, Dowling K, Meo P RN, Ahn J, Dolen E G.
Outpatients uterine artery embolization for symptomatic uterine fibroids: experience
in 49 patients.
JVIR.
2000;
11
305-311
- 23
Spies J B, Ascher S A, Roth A R, Kim J, Levy E, Gomez-Jorge J.
Uterine Artery Embolization for Leiomyomata.
Obstet Gyn.
2001;
98
29-34
- 24
Watson G M, Walker W J.
Uterine artery embolisation for the treatment of symptomatic fibroids in 114 women:
reduction in size of the fibroids and women's views of the sucess of the treatment.
BJOG.
2002;
109
129-135
- 25
Vashist A, Studd J, Carey A, Burn P.
Fatal septicaemia after fibroid embolisation.
Lancet.
1999;
354
307
- 26 Lanocita R, Frigerio L F, Patelli G. A fatal complication of percutaneous transcatheder
embolization for treatment of uterine fibroids. Society of minimal invasive therapy,
Boston, Mass 1999
- 27
De Blok S, de Vries C, Prinnsen H M, Bkaauwgeers H L, Jorna-Meijer L.
Fatal sepsis after uterine artery embolization with microspheres.
J Vasc Interv Radiol.
2003;
14
779-783
- 28
Makinen J, Johansson J, Tomas C, Heinonen P H, Laatikainen T, Kauko M, Heikkinen A M,
Sjöberg J.
Morbidity of 10 110 hysterectomies by type of approach.
Human Reprod.
2001;
16
1473-1478
- 29
Felemban A, Stein L, Tulandi T.
Uterine restoration after repeated expulsion of myomas after uterine artery embolization.
J Am Assoc Gynecol Laparosc.
2001;
8
442-444
- 30
Berkowitz R P, Hutchins F L, Worthington-Kirsch R L.
Vaginal expulsion of submucosal fibroids after uterine artery embolization. A report
of three cases.
J Reprod Med.
1999;
44
373-376
- 31
Pollard R R, Goldberg J M.
Prolapsed cervical myoma after uterine artera embolization. A case report.
J Reprod Med.
2001;
46
499-500
- 32
De Iaco P A, Muzzupapa G, Golfieri R, Ceccarini M, Roset B, Baroncini S.
A uterine wall defect after uterine artery embolization for symptomatic myomas.
Fertil Steril.
2002;
77
176
- 33
Shashoua A R, Stringer N H, Pearlman J B, Behrmaram B, Stringer E.
Ischemic uterine rupture and hysterectomy 3 months after uterine artery embolization.
J Am Assoc Gynecol Laparosc.
2002;
9
217-220
- 34
Huang L Y, Cheng Y F, Huang C C, Chang S Y, Kung F T.
Incomplete vaginal expulsion of pyoadenomyoma with sepsis and focal bladder necrosis
after uterine artery embolization for symptomatic adenomyosis: case report.
Hum Reprod.
2003;
18
167-171
- 35
Payne J F, Haney A F.
Serious complications of uterine artery embolization for conservative treatment of
fibroids.
Fertil Steril.
2003;
79
128-131
- 36
Sultana C J, Goldberg J, Aizenman L, Chon J K.
Vesicouterine fistula after uterine artery embolization: a case report.
Am J Obstet Gynecol.
2002;
187
1726-1727
- 37 Meyer W R. Embolization of uterine fibroids. RSNA, Chicago 2001
- 38
Spies J B, Roth A R, Gonsalves S M, Murphy-Skrzyniarz K M.
Ovarian function after uterine artery embolization for leiomyomata: assessment with
use of follicle stimulating hormone assay.
JVIR.
2001;
12
437-442
- 39
ACOG Committee Opinion .
Uterine artery embolizazion.
Obstet Gynecol.
2004;
103
403-404
- 40
Goldberg J, Pereira L, Berghella V.
Pregnancy after uterine artery embolization.
Obstet Gynecol.
2002;
100
869-872
- 41
Pron G, Mocarski E, Cohen M, Colgan T, Bennett J, Common A, Vilos G, Kung R.
Hysterectomy for complications after uterine artery embolization for leiomyoma: results
of a Canadian multicenter clinical trial.
J Am Assoc Gynecol Laparosc.
2003;
10
99-106
- 42
Marret H, Alonso A M, Cottier J P, Tranquart F, Herbreteau D, Body G.
Leiomyoma recurrence after uterine artery embolization.
J Vasc Interv Radiol.
2003;
14
1395-1399
- 43
Seracchioli R, Rossi S, Covoni F, Rossi E, Venturosi S, Buletti C, Flamini C.
Fertility and obstetric outcome after laparoscopic myomectomy of large myomata: a
randomized comparison with abdominal myomectomy.
Hum Reprod.
2000;
15
2663-2668
- 44
Fauconnier A, Chapron C, Babaki-Fard K, Dubuisson J B.
Recurrence of leiomyomata after myomectomy.
Hum Reprod Update.
2000;
6
595-602
- 45
Doridot V, Dubuisson J B, Chapron C, Fauconnier A, Babaki-Fard K.
Recurrence of leiomyomata after laparoscopic myomectomy.
J Am Assoc Gynecol Laparosc.
2001;
8
495-500
- 46
Takeuchi H, Kinoshita K.
Evaluation of adhesion formation after laparoscopic myomectomy by systematic second-look
microlaparoscopy.
J Am Assoc Gynecol Laparosc.
2002;
9
442-446
- 47
Malzoni M, Rotond M, Perone C, Labriola D, Ammaturo F, Izzo A, Panariello S, Rreich H.
Fertility after laparoscopic myomectomy of large uterine myomas: operative techniques
and preliminary results.
Eur J Gynaecol Oncol.
2003;
24
79-82
- 48
Sawin S W, Pilevsky N D, Berlin J A, Barnhart K T.
Comparability of perioperative morbidity between abdominal myomectomy and hysterectomy
for women with uterine leiomyomas.
Am J Obstet Gynecol.
2000;
183
1448-1455
- 49
Dubuisson J B, Fauconnier A, Deffarges J V, Norgaard C, Kreiker G, Chapron C.
Pregnancy outcome and deliveries following laparoscopic myomectomy.
Hum Reprod.
2000;
15
869-873
- 50
Propst A M, Liberman R F, Harlow B L, Ginsburg E S.
Complications of hysteroscopic surgery: predicting patients at risks.
Obstet Gynecol.
2000;
96
517-520
- 51
Jansen F W, Vredevoogd C B, Van Ulzen K, Hermans J, Trimbos J B, Trimbos-Kemper T CM.
Complications of Hysteroscopy: a prospective, multicenter study.
Obstet Gynecol.
2000;
96
266-270
- 52
Dubuisson J B, Fauconnier A, Chapron C, Kreiker G, Norgaard C.
Reproductive outcome after laparoscopic myomectomy in infertile women.
J Reprod Med.
2000;
45
23-30
- 53
Bernard G, Darai E, Poncelet G, Benifla J L, Madelenat P.
Fertilità after hysteroscopic myomectomy: effect of intramural myomas associated.
Eur J Obstet Gynecol Reprod Biol.
2000;
88
85-90
- 54
Fernandez H, Sefrioui O, Virelizier C, Gervaise A, Gomel V, Frydman R.
Hysteroscopic resection of submucosal myomas in patientin with infertility.
Hum Reprod.
2001;
16
1489-1492
- 55
Rossetti A, Sizzi O, Soranna L, Mancuso S, Lanzone A.
Fertility outcome: long-term results after laparoscopic myomectomy.
Gynecol Endocrinol.
2001;
15
129-134
- 56
Vercellini P, Zaina B, Yaylayan L, Pisacreta A, De Georgi O, Crosignani P G.
Hysteroscopic myomectomy: long-term effects on menstrual pattern and fertility.
Obstet Gynecol.
1999;
94
341-347
- 57
Donnez J, Squifflet J, Polet R, Nisolle M.
Laparoscopic myolysis.
Hum Reprod Update.
2000;
6
609-613
- 58
Liu W M, Ng H T, Wu Y C.
Laparoscopic bipolar coagulation of uterine vessels: a new method for treating symptomatic
fibroids.
Fertil Steril.
2001;
75
417-422
- 59
Istre O.
Laparoscopic occlusion of uterine vessels for the treatment of symptomatic fibroids:
initial experience and comparision to uterine artery embolization.
Am J Obstet Gynecol.
2004;
90 (1)
37-43
- 60
Kilkku P, Grönroos M, Hirvonen T, Rauramo L.
Supravaginal uterine amputation vs. hysterectomy. Effect on libido and orgasm.
Acta Obstet Gynecol Scand.
1983;
62
147-152
- 61
Kilkku P.
Supravaginal uterine amputation vs. hysterectomy. Effect on coital frequency and dyspareunia.
Acta Obstet Gynecol Scand.
1983;
62
141-145
- 62
Shaffer J I, Word A.
Hysterectomy - still a useful operation.
N Engl J Med.
2002;
347
1360-1362
- 63
Halttunen M.
Female sexuality does not need a uterine cervix: no need for subtotal hysterectomy.
Acta Obstet Gynecol Scand.
2004;
83
119-120
- 64
Barillot I, Horoit J C, Cuisenier J, Pigneux J, Schraub S, Rozan R, Pourquier H, Daly N,
Vrousos C, Keiling R.
Carcinoma of the cervical stump. A review of 213 cases.
Eur J Cancer.
1993;
29
1231-1236
- 65
Hellström A C, Sigurjonson T, Petterson F.
Carcinoma of the cervical stump. The Radiumhemmet series 1959-1987. Treatment and
prognosis.
Acta Obstet Gynecol Scand.
2001;
80
152-157
- 66
Okaro E O, Jones K D, Sutton C.
Long term outcome following laparoscopic supracervical hysterectomy.
BJOG.
2001;
108
1017-1020
- 67
Gimbel H, Zobbe V, Andersen B M, Filtenborg T, Gluud C, Tabor A.
Randomised controlled trial of total compared with subtotal hysterectomy with one-year
follow-up results.
BJOG.
2003;
110
1088-1098
PD Dr. R. Gaetje
Klinik für Gynäkologie und Geburtshilfe · Johann Wolfgang Goethe-Universität
Theodor Stern-Kai 7
60596 Frankfurt
Phone: 0 69-63 01-74 38
Fax: 0 69-63 01-70 34