Pathophysiologie der Sepsis (mit Videos)

Kernaussagen
Sepsis ist die systemische Reaktion auf eine Infektion, wobei als zentrale Komponenten dieser Reaktion Entzündungsmechanismen, Gerinnungsaktivierung, Endotheldysfunktion und Mikrozirkulationsschaden in Wechselwirkung treten.
Resultat ist in vielen Fällen eine vitale Bedrohung des Organismus durch Multiorgandysfunktion und -versagen.
Der Kenntnisstand über die zentralen Pathomechanismen der Sepsis ist in den letzten Jahren enorm gewachsen. Neue, aus diesem Wissen heraus abgeleitete Therapieansätze erbrachten im Rahmen klinischer Studien nur begrenzte Therapieerfolge, ohne die hohe Letalität bei Sepsis entscheidend zu senken.

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