Zusammenfassung
Eine wesentliche Voraussetzung für die qualitative und quantitative Beurteilung von
Penetrationsprozessen in und durch die Haarfollikel ist die Kenntnis von Morphologie
und Verteilung von Haarfollikeln am menschlichen Körper. In der Literatur finden sich
nur wenig Untersuchungen zur Verteilung und Morphologie von Haarfollikeln. Anhand
von Cyanacrylat-Oberflächenbiopsien wurde die Follikeldichte an sieben verschiedenen
Körperarealen bestimmt und mit den vorliegenden Daten aus der Literatur verglichen.
Zusätzlich erfolgte die Bestimmung der Haarfollikelgröße und die Kalkulation eines
potenziellen follikulären Reservoirs für topisch applizierte Substanzen. Die größte
Follikeldichte fand sich an der Stirn, wobei die Vergleichswerte aus der Literatur
deutlich höher lagen. Die Haarfollikelöffnungen nehmen an der Stirn den größten Anteil
an der Hautoberfläche ein. Das größte Follikelvolumen findet sich an der Wade. Die
Kalkulation des infundibulären Volumens für Stirn und Wade ist vergleichbar mit dem
potenziellen Reservoir des Stratum corneum. Die geringsten Werte für Dichte und Größenparameter
der Haarfollikel fanden sich an der Innenseite des Unterarms. Die vorliegende Zusammenstellung
zeigt, dass die Unterarminnenseite, die als Standardtestregion für Penetrationsuntersuchungen
topisch applizierter Substanzen verwendet wird, im Hinblick auf die Eigenschaften
der Haarfollikel nicht repräsentativ ist. Es wird deutlich, dass jede Körperregion
ihre eigenen Charakteristika bezüglich der Haarfollikel aufweist, die bei der Bewertung
von Penetrations- und Absorptionsuntersuchungen topisch applizierter Substanzen berücksichtigt
werden müssen.
Abstract
For quantitative and qualitative evaluation of skin penetration and absorption experiments,
the knowledge of morphology and distribution of hair follicles is mandatory. In the
literature, little information on hair follicle properties can be found. Follicular
density is determined in cyanoacrylate skin surface biopsies taken from different
skin areas. The findings were compared to the results found in the literature. Additionally,
characteristics of follicle sizes and potential follicular reservoir were measured
and calculated. The highest hair follicle density was found on the forehead, whereas
the results showed lower values compared to the findings already published. On the
forehead, the total area of follicle orifice shows the highest values, while the highest
average size of the follicular orifices was measured in the calf region. The highest
infundibular volume and, therefore, a potential follicular reservoir was calculated
for the forehead and for the calf region, although the calf region showed the lowest
hair follicle density. The calculated follicular volume of these two skin areas was
as high as the estimated reservoir of the stratum corneum. The lowest values for every
other parameter were found on the forearm. The inner forearm is a standard area for
percutaneous penetration and absorption experiments. The present investigation clearly
shows that the forearm is not representative regarding the follicular properties.
All body regions dispose their individual hair follicle characteristics, which, in
the future, should lead to a differential evaluation of skin penetration processes.
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Nina Otberg
Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin
Berlin
Schumannstr. 20/21 · 10117 Berlin
eMail: nina.otberg@charite.de
