The objective of this study was to examine risk factors for term or near-term fetal
growth restriction (FGR) in the absence of pregnancy complications. We completed a
survey of uncomplicated single live births delivered in Greater Beirut, Lebanon. FGR
cases were defined as below the 10th percentile of expected weight at gestational
age. Multivariate logistic regression was used to estimate odds ratios (OR) and 95%
confidence intervals (CIs). Main predictors of FGR were female gender (OR, 1.94; 95%
CI, 1.46 to 2.59), nulliparity (Or, 1.66; 95% CI, 1.25 ton 2.20), low prepregnancy
weight (OR, 2.52; 95% CI, 1.58 to 4.01), short stature (OR, 2.59; 95% CI, 1.57 to
4.28), and low pregnancy weight gain (OR, 1.75; 95% CI, 1.21 to 2.55). Anthropometric
characteristics of mothers are important modifiable determinants of fetal size in
our developing urban population of uncomplicated births.
KEYWORDS
Fetal growth restriction - pregnancy - epidemiology
REFERENCES
- 1
Bakketeig L S.
Current growth standards, definitions, diagnosis and classification of fetal growth
retardation.
Eur J Clin Nutr.
1998;
52
S1-S4
- 2
Clausson B, Cnattingius S, Axelsson O.
Preterm and term births of small for gestational age infants: a population-based study
of risk factors among nulliparous women.
Br J Obstet Gynecol.
1998;
105
1011-1017
- 3
De Onis M, Blössner M, Villar J.
Levels and patterns of intrauterine growth retardation in developing countries.
Eur J Clin Nutr.
1998;
52
S5-S15
- 4
Kramer M S.
Socioeconomic determinants of intrauterine growth retardation.
Eur J Clin Nutr.
1998;
52
S29-S33
- 5
Lapillonne A, Peretti N, Ho P S, Claris O, Salle B L.
Aetiology, morphology and body composition of infants born small for gestational age.
Acta Paediatr Suppl.
1997;
423
173-6
- 6
Bates J A, Evans J A, Mason G.
Differentiation of growth retarded from normally grown fetuses and prediction of intrauterine
growth retardation using Doppler ultrasound.
Br J Obstet Gynaecol.
1996;
103
670-675
- 7
Karlberg J, Albertsson-Wikland K, Baber F M, Low L CK, Yeung C Y.
Born small for gestational age: consequences for growth.
Acta Paediatr.
1996;
417(suppl)
8-13
- 8
Bakketeig L S, Jacobson U, Hoffman H J et al..
Prepregnancy risk factors of small-for-gestational age births among parous women in
Scandinavia.
Acta Obstet Gynecol Scand.
1993;
72
273-279
- 9
Abrams B, Newman V.
Small-for-gestational age at birth: maternal predictors and comparison with risk factors
of spontaneous preterm delivery in the same cohort.
Am J Obstet Gynecol.
1991;
164
875-890
- 10
Altman D G, Hytten F E.
Intrauterine growth retardation: Let's be clear about it (commentary).
Br J Obstet Gynaecol.
1989;
96
1127-1132
- 11
Wennergren M.
Perinatal risk factors: with special reference to intrauterine Growth retardation
and neonatal respiratory adaptation.
Acta Obstet Gynecol Scand Suppl.
1986;
135
9-18
- 12
Villar J, De Onis M, Kestler E, Bolanos F, Cerezo R, Bernedes H.
The differential neonatal morbidity of the intrauterine growth retardation syndrome.
Am J Obstet Gynecol.
1990;
163
151-157
- 13
Wennergren M, Wennergren G, Vlbergsson G.
Obstetric characteristics and neonatal performance in a four-year small for gestatioal
age population.
Obstet Gynecol.
1988;
72
615-620
- 14
Nordentolf M, Lou H, Hansen D et al..
Intrauterine growth retardation and premature delivery: the influence of maternal
smoking and psychosocial factors.
Am J Public Health.
1996;
86
347-354
- 15
Wen S W, Goldenberg R L, Cutter G R, Hoffman H J, Cliver S P.
Intrauterine growth retardation and preterm delivery: prenatal risk factors in an
indigent population.
Am J Obstet Gynecol.
1990;
162
213-218
- 16
Wen S W, Goldenberg R L, Cutter G R et al..
Smoking, maternal age, fetal growth, and gestational age at delivery.
Am J Obstet Gynecol.
1990;
162
53-58
- 17
Villar J, Belizan J M.
The relative contribution of prematurity and fetal growth retardation to low birth
weight in developing and developed societies.
Am J Obstet Gynecol.
1982;
143
793-798
- 18
Becerra J E, Smith J C.
Maternal smoking and low birthweight in the reproductive history of women in Puerto
Rico, 1982.
Am J Public Health.
1988;
78
268-272
- 19
Fikree F F, Berendes H W.
Risk factors for term intrauterine growth retardation: a community-based study in
Karachi.
Bull World Health Organ.
1994;
72
581-588
- 20
Guyer B, Hoyert D L, Martin J A, Ventura S J, MacDorman M E, Strobino D M.
Annual summary of vital Statistics-1998.
Pediatrics.
1999;
104
1229-1246
- 21
O'Campo P, Xue X, Wang M C, Caughy M O.
Neighborhood risk factors for low birthweight in Baltimore: a multilevel analysis.
Am J Public Health.
1997;
87
1113-1118
- 22
Golding J, Shenton T.
Low birth-weight and pre-term delivery in South-East Asia. The WHO international collaborative
study of hypertensive disorders of pregnancy.
Soc Sci Med.
1990;
30
497-502
- 23
Mamelle N, Laumon B, Lazar P.
Prematurity and occupational activity during pregnancy.
Am J Epidemiol.
1984;
119
309-322
- 24
Launer L J, Villar J, Kestler E, De Onis M.
The effect of maternal work on fetal growth and duration of pregnancy: a prospective
study.
Br J Obstet Gynecol.
1990;
97
62-70
- 25
Alexander G R, Himes J H, Kaufman R B, Mor J, Kogan M.
A United States national reference for fetal growth.
Obstet Gynecol.
1996;
87
163-168
- 26 George D, Mallery P. SPSS for Windows Step by Step: A Simple Guide and Reference,
11.0 Update. 4th ed. Ontario, Canada; Allyn and Bacon 1999
- 27
Schieve L A, Cogswell M E, Scanlon K S et al..
Prepregnancy body mass index and pregnancy weight gain: association with preterm delivery.
The NMLHS Collaborative Study Group.
Obstet Gynecol.
2000;
96
194-200
- 28
Hickey C A, Cliver S P, McNeal S F, Hoffmann H J, Goldenberg R L.
Prenatal weight gain patterns and birth weight among nonobese black and white women.
Obstet Gynecol.
1996;
88
490-496
- 29
Abrams B, Altman S L, Pickett K E.
Pregnancy weight gain: still controversial.
Am J Clin Nutr.
2000;
71(5 suppl)
1233S-1241S
- 30
Hickey C A, Cliver S P, Goldenberg R L, Kohatsu J, Hoffman H J.
Prenatal weight gain, term birth weight and fetal growth retardation among high-risk
multiparous black and white women.
Obstet Gynecol.
1993;
81
529-535
- 31
Croall J, Sherrif S, Matthews J.
Non-pregnant maternal plasma volume and fetal growth retardation.
Br J Obstet Gynaecol.
1978;
85
90-95
- 32
Gallery E DM, Hunyor S N, Gyory A Z.
Plasma volume contraction: a significant factor in both pregnancy associated hypertension
(pre-eclampsia) and chronic hypertension in pregnancy.
QJM.
1979;
48
593-602
- 33
Soffronoff E C, Kaufmann B M, Connaughton J F.
Intravascular volume determinations and fetal outcomes in hypertensive diseases of
pregnancy.
Am J Obstet Gynecol.
1977;
127
4-9
- 34
Salas S P, Rosso P, Espinoza R, Robert J A, Valdes G, Donoso E.
Maternal plasma volume expansion and hormonal changes in women with idiopathic fetal
growth retardation.
Obstet Gynecol.
1993;
81
1029-1033
- 35
Parti G, Marconi A M, Cetin I.
Placental-fetal interrelationship in IUGR fetuses: a review.
Placenta.
2002;
23(suppl A)
S136-S141
- 36
Mongelli M, Gardosi J.
Fetal growth.
Curr Opin Obstet Gynecol.
2000;
12
111-115
Khalid A YunisM.D.
Department of Pediatrics, American University of Beirut
New York Office, 850 3rd Avenue, 18th Floor
New York, NY 10022