Synthesis 2004(12): 2015-2025  
DOI: 10.1055/s-2004-829129
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Chiral α-Aminoalkylpyrimidines Using an Enantioselective Three-Component Reaction

Henry Dube, Nina Gommermann, Paul Knochel*
Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, München, Germany
Fax: +49(89)218077680; e-Mail: Paul.Knochel@cup.uni-muenchen.de;
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Publikationsverlauf

Received 5 April 2004
Publikationsdatum:
01. Juli 2004 (online)

Abstract

A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.