Synthesis of Chiral α-Aminoalkylpyrimidines Using an Enantioselective Three-Component Reaction

Henry Dube; Nina Gommermann; Paul Knochel

doi:10.1055/s-2004-829129

PAPER

Synthesis of Chiral α-Aminoalkylpyrimidines Using an Enantioselective Three-Component Reaction

Henry Dube, Nina Gommermann, Paul Knochel*
Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, München, Germany
Fax: +49(89)218077680; e-Mail: Paul.Knochel@cup.uni-muenchen.de;

Abstract

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Abstract

A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.

Key words

alkynes - asymmetric synthesis - C-H activation - copper catalysis - heterocycles

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References

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