Botulinum toxin is a potent toxin and powerful therapeutic tool. Botulinum toxin has
therapeutic application in the treatment of a host of neurological, ophthalmologic,
gastroenterological, urologic, and dermatologic conditions. Although there are issues
specific to each disorder for which botulinum toxin therapy is employed, there are
several common principles. This article reviews several of these general principles
by addressing common questions that arise in the therapeutic use of botulinum toxin.
Areas of focus include patient selection, drug preparation and delivery, use of electromyography
to guide injections, drug resistance, and organization of a therapeutic botulinum
toxin clinic.
KEYWORDS
Botulinum toxin - dystonia - therapy
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A. Gordon SmithM.D.
Department of Neurology, University of Utah, 30 North 1900 East
SOM Room 3R152, Salt Lake City, UT 84132-2305