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Planta Med 2005; 71(3): 268-272
DOI: 10.1055/s-2005-837827
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Sesquiterpenes from Erigeron annus

Xin Li1 , Min Yang1 , Yi-Feng Han1 , Kun Gao1
  • 1College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, People’s Republic of China
Weitere Informationen

Publikationsverlauf

Received: June 9, 2004

Accepted: October 12, 2004

Publikationsdatum:
15. März 2005 (online)

    Lizenzen und Reprints

Abstract

Four new and five known eudesmane-type sesquiterpenes were isolated from the aerial parts of Erigeron annus. The structures of these new compounds were elucidated by spectral means, including 2D-NMR analysis, to be 1β,4β-dihydroxyeudesman-11-ene; 1β,7α-dihydroxyeudesman-4(15)-ene; (1R,5S,6S,7S,10R)-1β, 6α-dihydroxyeudesman-4-one and 1β-D-glucopyranosyloxy-6α-hydroxyeudesman-4(15)-ene. In addition, a chemical transformation of a known compound 1β,6α-dihydroxy-eudesman-4 (15)-ene was carried out and the derivative 1β,6α-dihydroxy-4β(15)-epoxyeudesmane was obtained. Some of the compounds were evaluated for their in vitro antitumor activities.

Key words

Erigeron annus - Compositae - eudesmane - sesquiterpenes - antitumor activity

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Prof. Kun Gao

College of Chemistry and Chemical Engineering

State Key Laboratory of Applied Organic Chemistry

Lanzhou University

Lanzhou 730000

People’s Republic of China

Fax: +86-931-8912-582

eMail: npchem@lzu.edu.cn

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