Horm Metab Res 2005; 37(3): 189-190
DOI: 10.1055/s-2005-861296
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Short-term Cold and Hot Exposure on Total Plasma Ghrelin Concentrations in Humans

P.  J.  Tomasik1 , K.  Sztefko1 , M.  Pizon1
  • 1Department of Clinical Biochemistry, University Children’s Hospital, Jagiellonian University, Krakow, Poland
Further Information

Publication History

Received 2 June 2004

Accepted after revision 10 November 2004

Publication Date:
12 April 2005 (online)


Ghrelin is one of the peptides involved in the gut-brain axis. This 28-aminoacid peptide is primarily produced in the stomach and small intestine [1]. The first role of ghrelin to be determined involved the release of growth hormone [2], but later, the focus was placed on the role of this peptide in eating behavior and weight regulation [3] [4]. Ghrelin is upregulated during fasting; suggestions have been made that ghrelin is a signal of meal initiation [5]. Ambient temperature has been known to be a powerful metabolic regulator since the forties - a high environmental temperature results in decreased food intake, while a low environmental temperature leads to increased food intake [6]; however, the regulatory mechanism responsible for this phenomenon is still unclear. Therefore, the aim of this study was to investigate the relationship between plasma ghrelin levels and environmental temperature.


  • 1 Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Nature. 2000;  400 661-671
  • 2 Pombo M, Pombo C M, Garcia A, Caminos E, Gualillo O, Alvarez C V, Casanueva F F, Dieguez C. Horm Res. 2001;  55 Suppl 1 1-16
  • 3 Bizzarri C, Rigamonti A E, Giannone G, Berardinelli R, Cella S G, Cappa M, Muller E E. Horm Metab Res. 2004;  36 164-169
  • 4 Ott V, Fasshauer M, Dalski A, Meier B, Perwitz N, Klein H H, Tschop M, Klein J. Horm Metab Res. 2002;  34 640-645
  • 5 Cummings D E, Purnell J Q, Frayo R S, Schmidova K, Wisse B E, Weigle D S. Diabetes. 2001;  50 1714-1719
  • 6 Brobeck J R. 1948 (classical article) Obesity Research. 1997;  5 641-645
  • 7 Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. Nature. 2001;  409 194-198
  • 8 Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K. Circulation. 2001;  104 2034-2038
  • 9 Wren A M, Seal L J, Cohen M A, Brynes A E, Frost G S, Murphy K G, Dhillo W S, Ghatei M A, Bloom S R. J Clin Endocrinol Metab. 2001;  86 5992-5995
  • 10 Bjerkedal T, Beckstrom J R, Brevik J I, Skaden K. Tidsskrift for Den Norske Laegeforening. 2001;  121 674-677
  • 11 Meyer H E, Falach J A, O'Neill T, Tverdal A, Varlow J. Bone. 1995;  17 347-350
  • 12 Lucidi P, Murdolo G, di Loreto C, Parlanti N, de Cicco A, Ranchelli A, Fatone C, Taglioni C, Fanelli C, Santeusanio F, De Feo P. J Endocrinol Invest. 2004;  27 RC12-15

Dr. Przemyslaw J. Tomasik

Department of Clinical Biochemistry · University Children’s Hospital ·

Wielicka St. 265 · 30663 Krakow · Poland

Fax: +48 (12) 658 06 81

Email: mitomasi@cyf-kr.edu.pl