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Synthesis 2005(6): 993-997
DOI: 10.1055/s-2005-861849
DOI: 10.1055/s-2005-861849
PAPER
© Georg Thieme Verlag Stuttgart · New York
Preparation of Cyanopyridines by Direct Cyanation
Weitere Informationen
Received
22 October 2004
Publikationsdatum:
10. März 2005 (online)
Publikationsverlauf
Publikationsdatum:
10. März 2005 (online)
Abstract
After pretreatment with nitric acid and trifluoroacetic anhydride, aqueous potassium cyanide converted pyridines 1a-l into their corresponding 2-cyano derivatives 4a-l in an average yield of 52%.
Key words
pyridines cyanation - concd nitric acid - TFAA - potassium cyanide
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