Synthesis 2005(7): 1083-1086  
DOI: 10.1055/s-2005-861872
PAPER
© Georg Thieme Verlag Stuttgart · New York

A New [5+1]-Annulation Route to Some Quinazoline and Fused Pyrimidine Derivatives

Shital K. Chattopadhyay*, Rajat Dey, Suman Biswas
Department of Chemistry, University of Kalyani, Kalyani 741235, India
Fax: +91(33)25828282; e-Mail: skchatto@yahoo.com;
Further Information

Publication History

Received 23 September 2004
Publication Date:
17 March 2005 (eFirst)

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Abstract

β-Dicarbonyl compounds, such as diethyl malonate, ethyl acetoacetate and acetyl acetone have been found to add selectively to the iminoether functionality of the 2-ethoxymethyleneaminonitriles leading to a one-pot synthesis of some quinazoline and fused pyrimidine derivatives.

Key words

annulations - heterocycles - nitriles - Lewis acids - tin

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