Acid-Rich Peptides are Prone to Damage under Fenton Conditions - Split-and-Mix Libraries for the Detection of Selective Peptide Cleavage

Matthias Nold; Kirsten Koch; Helma Wennemers

doi:10.1055/s-2005-865329

PAPER

Acid-Rich Peptides are Prone to Damage under Fenton Conditions - Split-and-Mix Libraries for the Detection of Selective Peptide Cleavage

Matthias Nold, Kirsten Koch, Helma Wennemers*
Department of Chemistry, University of Basel, St. Johanns Ring 19, 4056 Basel, Switzerland
Fax: +41(61)2670976; e-Mail: Helma.Wennemers@unibas.ch;

Abstract

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Abstract

Acid-rich peptides are damaged under Fenton conditions to a greater extent than others as revealed by combinatorial screenings. The higher damage propensity is due to Fe-complexation that leads to the generation of radicals in close vicinity and thereby to the cleavage of the backbone of acid-rich peptides.

Key words

combinatorial chemistry - Fenton reaction - peptides - split-and-mix synthesis - peptide cleavage

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References

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