Asymmetric Zn Aldol Additions: Asymmetric Synthesis of Fostriecin

B. M. Trost; M. U. Frederiksen; J. P. N. Papillion; P. E. Harrington; S. Shin; B. T. Shireman

doi:10.1055/s-2005-865347

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Synfacts 2005(0): 0010-0010
DOI: 10.1055/s-2005-865347

Synthesis of Natural Products and Drugs

Asymmetric Zn Aldol Additions: Asymmetric Synthesis of Fostriecin

Contributor(s): Philip Kocienski
B. M. Trost*, M. U. Frederiksen, J. P. N. Papillion, P. E. Harrington, S. Shin, B. T. Shireman
Stanford University, USA

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Publication History

Publication Date:
20 July 2005 (online)

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Significance

Fostriecin is a metabolite of Streptomyces pulveraceous. It is a potent inhibitor of protein phosphatase 2A and it is cytotoxic towards leukemia and many other cell lines.