A New Approach to the Synthesis of Selectively Protected (2S)-1,2,4-Triaminobutane Derivatives

Adam P. Treder; Aleksandra Walkowiak; Włodzimierz Zgoda; Ryszard Andruszkiewicz

doi:10.1055/s-2005-869989

SHORTPAPER

A New Approach to the Synthesis of Selectively Protected (2S)-1,2,4-Triaminobutane Derivatives

Adam P. Treder*^a, Aleksandra Walkowiak^a, Włodzimierz Zgoda^b, Ryszard Andruszkiewicz^a
^a Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, G. Narutowicza St 11/12, 80-952 Gdańsk, Poland
Fax: +48(58)3471144; e-Mail: ryszarda@chem.pg.gda.pl;
^b Department of Medicinal Chemistry, Medical University of Gdańsk, Dūbinki St 1, 80-952 Gdańsk, Poland

Abstract

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Abstract

An efficient synthesis of selectively protected (2S)-1,2,4-triaminobutane from l-glutamic acid via (2S)-N ⁴-benzyloxycarbonyl-2,4-diaminobutanamid is described.

Key words

amides - amines - amino acids - protecting groups - reductions

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References

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