Brosimacutins J - M, Four New Flavonoids from Brosimum acutifolium and their Cytotoxic Activity

Abstract

Four new flavonoids, brosimacutins J - M (1 - 4), were isolated from the bark of Brosimum acutifolium Huber together with a known flavan, brosimine A (5). The structures of compounds 1 - 4 were elucidated by spectroscopic means. 27 constituents of this plant including compounds 1 - 5 were evaluated for their cytotoxic activity against murine leukemia P388 cells. Although no compounds tested had any reversal effect on vincristine resistance, brocimacutins J - M (1 - 4) were cytotoxic to vincristine-resistant P388 cells (IC₅₀ 4.4 - 19 μg/mL).

Key words

Brosimum acutifolium - Moraceae - flavans - chalcones - cytotoxic activity

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