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Synfacts 2005(1): 0102-0102
DOI: 10.1055/s-2005-872158
DOI: 10.1055/s-2005-872158
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Total Synthesis of (+)-Pseudodistomin D
B. M. Trost*, D. R. Fandrick
Stanford University, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2005 (online)
Significance
The alkaloid Pseudodistomin D was isolated from the ascidian Pseudodistomina megalarva along with pseudodistomins B, C, E and F. The biological activities of these compounds include calmodulin antagonist activity and cytotoxicity against several cancer cell lines. This first total synthesis confirms the absolute stereochemistry of the natural product.