Regio- and Stereoselective Synthesis of Structurally Diverse Polycyclic Indolyldiamines
S. Cutri, A. Diez*, M. Bonin*, L. Micouin, H.-P. Husson
Université René Descartes Paris, France and Parc Científic de Barcelona, Spain
21. September 2005 (online)
Starting from a common chiral 2-cyano-6-oxazolopiperidine precursor, regio- and stereoselective routes to four structurally different indolyldiamines are reported. The reaction sequence involves a reductive and alkylative ring enlargement process and proceeds in low to modest overall yields. Its significance is in the rapid access of diverse analogues of known alkaloids.