Synfacts 2005(1): 0123-0123  
DOI: 10.1055/s-2005-916017
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Fluorination and Chlorination of Compounds Capable of Two-Point Binding

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
N. Shibata*, J. Kohno, K. Takai, T. Ishimaru, S. Nakamura, T. Toru*, S. Kanemasa
Nagoya Institute of Technology and Kyushu University, Japan
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21. September 2005 (online)


Asymmetric halogenation has emerged as an important organic reaction due to the variety of drugs that contain fluorine and the synthetic utility of chiral carbon centers with chlorine substituents. These authors describe a highly enantioselective protocol catalyzed by a chiral Ni(II) complex.