Chiral Brønsted Acid Catalyzed Hydrophosphonylation of Imines
T. Akiyama*, H. Morita, J. Itoh, K. Fuchibe
Gakushuin University, Japan
21 September 2005 (online)
The authors present a useful chiral Brønsted acid that catalyzes the hydrophosphonylation of imines. This catalyst is prepared relatively easily and the reaction proceeds under mild conditions (room temperature). With a catalyst loading of 10 mol%, many examples give yields over 90% and ee’s over 85%.