Zusammenfassung
Die Erkenntnis, dass die Sicherstellung einer ausreichenden Selenversorgung einen
wesentlichen Beitrag zur Prävention und Therapie von Autoimmunthyreopathien leistet,
zählt zu den wichtigsten Innovationen in der Thyreologie der letzten Jahre. Mehrere
publizierte Studien dokumentieren bei der Immunthyreoiditis Hashimoto eine therapeutische
und präventive Wirkung, wenn die konventionelle Gabe von L-Thyroxin mit Selen in therapeutischer
Dosierung (200 μg/d) kombiniert wird. Bislang noch nicht publizierte Daten bestätigen
den Nutzen einer ausreichend hohen Selenzufuhr auch bei der zweiten wichtigen Immunthyreopathie,
dem Morbus Basedow, sowie der damit eng assoziierten endokrinen Orbitopathie.
Abstract
Provision of adequate selenium supply has recently been recognized as a fundamental
step towards better treatment and prevention of autoimmune thyroid disorders. As documented
by at least two randomized controlled clinical studies, addition of sufficient amounts
of selenium (200 μg/d) to conventional replacement with levothyroxine will improve
the clinical and immunological course of patients with Hashimoto's thyroiditis. Moreover,
yet unpublished data suggest that therapeutic doses of selenium will also improve
the course of patients with Graves' disease, and most notably, of those afflicted
by the closely associated condition of active ophthalmopathy.
Schlüsselwörter
Immunthyreoiditis - Hashimoto-Thyreoiditis - Morbus Basedow - endokrine Orbitopathie
- Selen - Immunregulation
Keywords
Thyroiditis - Hashimoto's disease - Graves' disease - thyroid-associated ophthalmopathy
- selenium - immunoregulation
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Korrespondenzadresse
Prof. Dr. med. Armin E. Heufelder
Internist und Endokrinologe
Elisenstr. 3A
80335 München
Email: endoc@web.de
