Lignans from Saussurea conica and their NO Production Suppressing Activity

Abstract

Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. Six 2,3-dibenzylbutyrolactone-type lignans were biologically evaluated, and two of them, arctigenin and matairesinol, showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.

Saussurea conica - Asteraceae - conicaols A and B - conicaoside - NO production suppressing activity

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