Planta Med 2006; 72(8): 746-750
DOI: 10.1055/s-2006-941504
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New and Bioactive Aromatic Compounds from Zanthoxylum zanthoxyloides

Emerson F. Queiroz1 , Anne-Emmanuelle Hay1 , Fatima Chaaib1 , Daphné van Diemen1 , Drissa Diallo2 , Kurt Hostettmann1
  • 1Laboratoire de Pharmacognosie et Phytochimie, Ecole de Pharmacie Genève-Lausanne, Université de Genève, Genève, Switzerland
  • 2Département de Médecine Traditionnelle, INSRP, Bamako, Mali
Further Information

Publication History

Received: October 17, 2005

Accepted: April 14, 2006

Publication Date:
19 June 2006 (online)

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Abstract

In the course of a study of medicinal plants from Mali, the root bark of Zanthoxylum zanthoxyloides Lam. (Rutaceae) was investigated. The root bark of this plant is used as a toothbrush by West African people. Phytochemical investigation of the MeOH extract of Zanthoxylum zanthoxyloides Lam. (Rutaceae) led to the isolation of different biologically active compounds. The separation of acetylcholinesterase inhibitors was performed by centrifugal partition chromatography (CPC). The fractions were monitored by direct TLC bioautographic assays. The bio-guided isolation led to the isolation of a new peroxide derivative. In addition, LC/UV/MS analysis performed on the crude MeOH extract allowed on-line identification of some known compounds. The structures of the isolated compounds were elucidated by classical spectroscopic methods including UV, NMR, MS and HR-MS.

References

Prof. Kurt Hostettmann

Laboratoire de Pharmacognosie et Phytochimie

Ecole de Pharmacie Genève-Lausanne

Université de Genève

Quai Ernest Ansermet 30

1211 Genève 4

Switzerland

Phone: +41-22-379-3401

Email: kurt.hostettmann@pharm.unige.ch